Localization of [3H]cyclohexyladenosine and [3H]nitrobenzylthionosine binding sites in rat striatum and superior colliculus

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19 Scopus citations

Abstract

The localization of adenosine receptors labelled with [3H]cyclohexyladenosine ([3H]CHA) and adenosine transport sites labelled with [3H]nitrobenzylthioinosine ([3H]NBI) was examined in striatum and superior colliculus (SC) using radioligand binding and lesioning methods. Striatal kainic acid lesions significantly reduced the number (Bmax) of a single class of high affinity binding sites for [3H]CHA by 50% and that for [3H]NBI by 15% without altering Kd values for either ligand. In SC, enucleations significantly reduced both high and low affinity [3H]CHA binding sites by about 60% while levels of [3H]NBI binding were unaffected. Thus, adenosine receptors are present on striatal interneurons and retinal projections to the SC and some [3H]NBI binding sites are located on striatal interneurons.

Original languageEnglish (US)
Pages (from-to)404-408
Number of pages5
JournalBrain Research
Volume363
Issue number2
DOIs
StatePublished - Jan 22 1986

Keywords

  • adenosine receptor
  • cyclohexyladenosine
  • nitrobenzylthioinosine
  • nucleoside transport site
  • striatum
  • superior colliculus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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