TY - JOUR
T1 - Localization of the central pressor action of bradykinin to the cerebral third ventricle
AU - Lewis, R. E.
AU - Phillips, M. I.
PY - 1984
Y1 - 1984
N2 - Bradykinin injected into the lateral ventricle produces a rise in blood pressure. Cream plugs selectively localized to discrete regions of the ventricular system were used to block drug access to periventricular sites. Third ventricular plugs blocked the pressor response to lateral ventricular injections of 5 μg bradykinin (27 ± 5 before vs. 5 ± 5 mmHg after plug, n = 7) and 100 ng angiotensin II (22 ± 3 before vs. 4 ± 2 mmHg after plug, n = 5). Third ventricular plugs also suppressed the drinking response to angiotensin II (3.7 ± 0.6 before vs. 0.9 ± 0.6 ml after plug, n = 5). However, plugs that occluded the fourth ventricle failed to suppress the central bradykinin pressor response (27 ± 8 before vs. 35 ± 9 mmHg after plug, n = 5). The data suggest that the central bradykinin pressor response has a site of action similar to that of angiotensin II in the ventral third ventricle.
AB - Bradykinin injected into the lateral ventricle produces a rise in blood pressure. Cream plugs selectively localized to discrete regions of the ventricular system were used to block drug access to periventricular sites. Third ventricular plugs blocked the pressor response to lateral ventricular injections of 5 μg bradykinin (27 ± 5 before vs. 5 ± 5 mmHg after plug, n = 7) and 100 ng angiotensin II (22 ± 3 before vs. 4 ± 2 mmHg after plug, n = 5). Third ventricular plugs also suppressed the drinking response to angiotensin II (3.7 ± 0.6 before vs. 0.9 ± 0.6 ml after plug, n = 5). However, plugs that occluded the fourth ventricle failed to suppress the central bradykinin pressor response (27 ± 8 before vs. 35 ± 9 mmHg after plug, n = 5). The data suggest that the central bradykinin pressor response has a site of action similar to that of angiotensin II in the ventral third ventricle.
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U2 - 10.1152/ajpregu.1984.247.1.r63
DO - 10.1152/ajpregu.1984.247.1.r63
M3 - Article
C2 - 6742236
AN - SCOPUS:0021464918
SN - 0363-6119
VL - 16
SP - R63-R68
JO - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
JF - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
IS - 1
ER -