Localization of the human fibronectin (FN) gene on chromosome 8 by a specific enzyme immunoassay

Stephen I. Rennard, Robert L. Church, David H. Rohrbach, Dolores E. Shupp, Shigeto Abe, A. Tyl Hewitt, J. Clifford Murray, George R. Martin

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The fibronectin produced by clonal murine-human hybrid cell lines containing various complements of human chromosomes was measured. Human and murine fibronectins were assayed by specific immunoassay, and the production of human fibronectin was correlated with karyology and isozyme markers for specific human chromosomes. The data show a 100% concordance between the expression of human fibronectin and glutathione reductase, a marker for human chromosome 8, indicating that chromosome 8 codes for the fibronectin polypeptide.

Original languageEnglish (US)
Pages (from-to)551-566
Number of pages16
JournalBiochemical Genetics
Volume19
Issue number5-6
DOIs
StatePublished - Jun 1981

Keywords

  • ELISA
  • fibronecting
  • gene mapping
  • murine-human hybrids

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry
  • Molecular Biology
  • Genetics

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