Localized gene action controlling intestinal neoplasia in mice

Karen A. Gould, William F. Dove

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Mice heterozygous for the Apc(min) (Min) mutation develop adenomas throughout the intestinal tract. Apc is believed to be involved in cell migration, adhesion, and polarity. Adenoma multiplicity and growth rate are modulated by an unlinked modifier locus, Mom1. The secretory phospholipase Pla2g2a is a candidate for Mom1. Here, we investigate the range of action of Apc and Mom1. Analysis of chimeric Min mice indicates that the actions of both Apc and Mom1 are localized within the cell lineage that gives rise to intestinal tumors.

Original languageEnglish (US)
Pages (from-to)5848-5853
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume94
Issue number11
DOIs
StatePublished - May 27 1997

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