Long non-coding RNAs and nuclear factor-κB crosstalk in cancer and other human diseases

Subash C. Gupta, Nikee Awasthee, Vipin Rai, Srinivas Chava, Venugopal Gunda, Kishore B. Challagundla

Research output: Contribution to journalReview articlepeer-review

79 Scopus citations


The regulation of the pleiotropic transcription factor, nuclear factor-κB (NF-κB) by miRNAs and proteins is extensively studied. More recently, the NF-κB signaling was also reported to be regulated by several long non-coding RNAs (lncRNAs) that constitute the major portion of the noncoding component of the human genome. The common NF-κB associated lncRNAs include NKILA, HOTAIR, MALAT1, ANRIL, Lethe, MIR31HG, and PACER. The lncRNA and NF-κB signaling crosstalk during cancer and other diseases such as cardiomyopathy, celiac disease, cerebral infarction, chronic kidney disease, diabetes mellitus, Kawasaki disease, pregnancy loss, and rheumatoid arthritis. Some NF-κB related lncRNAs can affect gene expression without modulating NF-κB signaling. Most of the lncRNAs with a potential to modulate NF-κB signaling are regulated by NF-κB itself suggesting a feedback regulation. The discovery of lncRNAs have provided a new type of regulation for the NF-κB signaling and thus could be explored for therapeutic interventions. The manner in which lncRNA and NF-κB crosstalk affects human pathophysiology is discussed in this review. The challenges associated with the therapeutic interventions of this crosstalk are also discussed.

Original languageEnglish (US)
Article number188316
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Issue number1
StatePublished - Jan 2020


  • Cancer
  • Chronic disease
  • LncRNA
  • NF-κB
  • Non-coding RNA

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research


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