TY - JOUR
T1 - Long term dose response study of N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide-induced urinary bladder carcinogenesis
AU - Arai, Masayuki
AU - John, Margaret St
AU - Fukushima, Shoji
AU - Friedell, Gilbert H.
AU - Cohen, Samuel M.
N1 - Funding Information:
This work was supported in part by USPHS Grant CA32513 from the National Cancer Institute through the National Bladder Cancer Project. The authors thank Jan Leemkuil for her assistance in the preparation of this manuscript.
PY - 1983/4
Y1 - 1983/4
N2 - The effect of dose was evaluated for the bladder carcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT). The chemical was fed to male weanling F344 rats for 30 weeks followed by 74 weeks of control diet. The incidences of bladder carcinoma were 100, 100, 87, 0, 0 and 0% for doses of 0.2, 0.1, 0.05, 0.01, 0.005 and 0.001%, respectively. There was an inverse relationship between dose and latency period. There was no increased incidence of tumors of other tissues.
AB - The effect of dose was evaluated for the bladder carcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT). The chemical was fed to male weanling F344 rats for 30 weeks followed by 74 weeks of control diet. The incidences of bladder carcinoma were 100, 100, 87, 0, 0 and 0% for doses of 0.2, 0.1, 0.05, 0.01, 0.005 and 0.001%, respectively. There was an inverse relationship between dose and latency period. There was no increased incidence of tumors of other tissues.
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U2 - 10.1016/0304-3835(83)90234-3
DO - 10.1016/0304-3835(83)90234-3
M3 - Article
C2 - 6850560
AN - SCOPUS:0020522960
SN - 0304-3835
VL - 18
SP - 261
EP - 269
JO - Cancer Letters
JF - Cancer Letters
IS - 3
ER -