Long-term Management of Panuveitis and Choroidal Mass Associated with Rosai Dorfman Disease with Pegylated Interferon

Lucas Kim, J. Clay Bavinger, Jessica G. Shantha, Anastasios Costarides, Hans E. Grossniklaus, Steven Yeh

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Purpose: To present a patient with Rosai-Dorfman Disease (RDD), a histiocytic proliferative disorder typified by lymphadenopathy with rare ocular manifestations, who developed panuveitis that responded to pegylated interferon. Methods: Descriptive case report of a patient with RDD with multi-organ involvement including ocular manifestations including bilateral panuveitis with choroidal masses. Results: A 54-year-old African American woman with known systemic RDD of the breast, lung, and gastrointestinal tract presented with panuveitis with choroidal masses in both eyes. Her systemic and ocular disease initially responded well to oral and topical steroid therapy. Later, however, her systemic disease progressed with multiple muscular and bony lesions. Systemic therapy was switched to pegylated interferon, a cytokine with antiviral, antitumor and immunomodulatory activity. After 14 months of therapy with pegylated interferon, the patient’s systemic and ocular disease stabilized. Conclusion: Rosai-Dorfman disease may be complicated by panuveitis and choroidal masses that may respond to pegylated interferon with stabilization of systemic and ocular manifestations. A multi-disciplinary approach is essential given the unique diagnostic and management challenges of RDD.

Original languageEnglish (US)
Pages (from-to)1078-1082
Number of pages5
JournalOcular Immunology and Inflammation
Issue number5
StatePublished - 2022
Externally publishedYes


  • Rosai-Dorfman disease
  • histiocytes; choroidal mass
  • panuveitis
  • pegylated interferon

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology


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