Long-term results of intestinal transplantation for pseudo-obstruction in children

K. Iyer, S. Kaufman, D. Sudan, S. Horslen, B. Shaw, I. Fox, A. Langnas, J. Reyes

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Purpose: The aim of this study was to determine long-term results of intestinal transplantation in children with pseudo-obstruction, particularly when stomach and colon are not part of the allograft. Methods: The authors conducted a case-record review of all children who underwent transplantation at our center for a primary diagnosis of pseudo-obstruction. Supplementary information was obtained from outpatient charts, computerized database, and telephone survey of parents. Results: Six small bowel and 3 liver-small bowel tranplants were carried out in 8 patients between 1993 and 1999. Median follow-up is 40 months (range, 13 to 73 months). Median age at transplantation was 2.7 years (range, 0.7 to 12.8 years). Median graft survival in this series is 15 months (range, 1 day to 71 months). Stomach and colon were excluded from all allografts. Two children died 5 and 368 days after transplant and 2 graft losses occurred in 1 patient. Two children had lymphoproliferative disease; both are alive with functioning grafts. Five survivors with functioning grafts recieve full enteral feedings at home. Four of the 5 have had ileostomies closed, and 3 have normal bowel movements. Conclusions: Intestinal transplantation without stomach or colon provides children with cronic intestinal pseudo-obstruction with a good quality of life. The underlying disease poses special challenges in management.

Original languageEnglish (US)
Pages (from-to)174-177
Number of pages4
JournalJournal of pediatric surgery
Issue number1
StatePublished - 2001


  • Intestinal failure
  • Intestinal transplantation
  • Pseudo-obstruction

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health


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