Longitudinal analysis of lymphocyte ratios and HIV-1 intracellular DNA levels in children

Akihiko Saitoh, Christine A. Powell, Terence Fenton, Steven D. Douglas, Stuart E. Starr, Courtney V. Fletcher, Stephen A. Spector

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The associations between human immunodeficiency virus type 1 (HIV-1) intracellular DNA and immunological markers were analyzed longitudinally for children with sustained, undetectable RNA levels while receiving highly active antiretroviral therapy (HAART) for >2 years. When DNA levels reached a plateau at week 104 of therapy, in contrast to findings for adults, there was no correlation between the CD4 +:CD8 + ratio and DNA levels (r = -0.02; P = .95), and naive CD4 +CD45RA + lymphocytes predominated. These data suggest that the increased proportion of naive lymphocytes found in children are less susceptible to HIV-1 infection than are the memory lymphocytes that dominate immune reconstitution in adults.

Original languageEnglish (US)
Pages (from-to)1216-1220
Number of pages5
JournalJournal of Infectious Diseases
Volume189
Issue number7
DOIs
StatePublished - Apr 1 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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