TY - JOUR
T1 - Longitudinal screening detects cognitive stability and behavioral deterioration in ALS patients
AU - Woolley, Susan
AU - Goetz, Ray
AU - Factor-Litvak, Pam
AU - Murphy, Jennifer
AU - Hupf, Jonathan
AU - Lomen-Hoerth, Catherine
AU - Andrews, Howard
AU - Heitzman, Daragh
AU - Bedlack, Richard
AU - Katz, Jonathan
AU - Barohn, Richard
AU - Sorenson, Eric
AU - Oskarsson, Bjorn
AU - Filho, Americo Fernandes
AU - Kasarskis, Edward
AU - Mozaffar, Tahseen
AU - Nations, Sharon
AU - Swenson, Andrea
AU - Koczon-Jaremko, Agnes
AU - Christodoulou, Georgia
AU - Mitsumoto, Hiroshi
N1 - Publisher Copyright:
© 2018 Susan Woolley et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
PY - 2018
Y1 - 2018
N2 - Objective: To evaluate longitudinal cognitive/behavioral change over 12 months in participants enrolled in the ALS Multicenter Cohort Study of Oxidative Stress (ALS COSMOS). Methods: We analyzed data from 294 ALS participants, 134 of whom were studied serially. Change over time was evaluated controlling for age, sex, symptom duration, education, race, and ethnicity. Using multiple regression, we evaluated associations among decline in ALS Functional Rating Scale-Revised (ALSFRS-R) scores, forced vital capacity (FVC), and cognitive/behavioral changes. Change in cognitive/behavioral subgroups was assessed using one-way analyses of covariance. Results: Participants with follow-up data had fewer baseline behavior problems compared to patients without follow-up data. We found significant worsening of behavior (ALS Cognitive Behavioral Screen (ALS CBS) behavioral scale, p < 0 001; Frontal Behavioral Inventory-ALS (FBI-ALS) disinhibition subscale, p = 0 044). Item analysis suggested change in frustration tolerance, insight, mental rigidity, and interests (p < 0 05). Changes in ALSFRS-R correlated with the ALS CBS. Worsening disinhibition (FBI-ALS) did not correlate with ALSFRS-R, FVC, or disease duration. Conclusion: We did not detect cognitive change. Behavioral change was detected, and increased disinhibition was found among patients with abnormal baseline behavioral scores. Disinhibition changes did not correlate with disease duration or progression. Baseline behavioral problems were associated with advanced, rapidly progressive disease and study attrition.
AB - Objective: To evaluate longitudinal cognitive/behavioral change over 12 months in participants enrolled in the ALS Multicenter Cohort Study of Oxidative Stress (ALS COSMOS). Methods: We analyzed data from 294 ALS participants, 134 of whom were studied serially. Change over time was evaluated controlling for age, sex, symptom duration, education, race, and ethnicity. Using multiple regression, we evaluated associations among decline in ALS Functional Rating Scale-Revised (ALSFRS-R) scores, forced vital capacity (FVC), and cognitive/behavioral changes. Change in cognitive/behavioral subgroups was assessed using one-way analyses of covariance. Results: Participants with follow-up data had fewer baseline behavior problems compared to patients without follow-up data. We found significant worsening of behavior (ALS Cognitive Behavioral Screen (ALS CBS) behavioral scale, p < 0 001; Frontal Behavioral Inventory-ALS (FBI-ALS) disinhibition subscale, p = 0 044). Item analysis suggested change in frustration tolerance, insight, mental rigidity, and interests (p < 0 05). Changes in ALSFRS-R correlated with the ALS CBS. Worsening disinhibition (FBI-ALS) did not correlate with ALSFRS-R, FVC, or disease duration. Conclusion: We did not detect cognitive change. Behavioral change was detected, and increased disinhibition was found among patients with abnormal baseline behavioral scores. Disinhibition changes did not correlate with disease duration or progression. Baseline behavioral problems were associated with advanced, rapidly progressive disease and study attrition.
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U2 - 10.1155/2018/5969137
DO - 10.1155/2018/5969137
M3 - Article
C2 - 30515252
AN - SCOPUS:85060544675
SN - 0953-4180
VL - 2018
JO - Behavioural Neurology
JF - Behavioural Neurology
M1 - 5969137
ER -