TY - JOUR
T1 - Longitudinal spectral domain optical coherence tomography changes in eyes with intraocular lymphoma
AU - Jang, Hyun Soo
AU - Sepah, Yasir J.
AU - Sophie, Raafay
AU - Bittencourt, Millena G.
AU - Ferraz, Daniel
AU - Hanout, Mostafa
AU - Liu, Hongting
AU - Do, Diana V.
AU - Nguyen, Quan Dong
N1 - Funding Information:
QDN is the recipient of the Physician Scientist Award from the Research to Prevent Blindness. DF is the recipient of the award from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. DVD is the recipient of the Heed Ophthalmic Foundation Clinician-Scientist Award. YJS is the Director of the Ocular Imaging Research and Reading Center at the Stanley M. Truhlsen Eye Institute. RS, MH, HL and MGB are postdoctoral research fellows at the Retinal Imaging Research and Reading Center.
PY - 2013
Y1 - 2013
N2 - Background: Cases of patients with primary intraocular lymphoma (PIOL) were retrospectively analyzed to describe the longitudinal intra-retinal morphological changes in PIOL as visualized on images obtained by spectral domain optical coherence tomography (SD-OCT). Results: In a retrospective case series, Heidelberg Spectralis SD-OCT images obtained in the longitudinal evaluation of patients with biopsy-proven PIOL were analyzed and assessed. The images were graded for the presence of macular edema (ME), pigment epithelial detachment (PED), subretinal fluid (SRF), and hyperreflective signals. SD-OCT scans of five eyes from five patients were assessed. Patients showed signs of inflammation, such as ME and SRF, which were resolved with treatments in some cases. Hyperreflective signals were found in all eyes in the form of nodules or bands across the retina, with the highest frequency of appearance in the ganglion cell layer, inner plexiform layer, photoreceptor layer, and retinal pigment epithelium; such signals increased with the progression of PIOL. Conclusion: SD-OCT may be employed to monitor the progression of PIOL. Hyperreflective signals on OCT may correspond with increase in disease activities, along with other findings such as ME, PED, and SRF.
AB - Background: Cases of patients with primary intraocular lymphoma (PIOL) were retrospectively analyzed to describe the longitudinal intra-retinal morphological changes in PIOL as visualized on images obtained by spectral domain optical coherence tomography (SD-OCT). Results: In a retrospective case series, Heidelberg Spectralis SD-OCT images obtained in the longitudinal evaluation of patients with biopsy-proven PIOL were analyzed and assessed. The images were graded for the presence of macular edema (ME), pigment epithelial detachment (PED), subretinal fluid (SRF), and hyperreflective signals. SD-OCT scans of five eyes from five patients were assessed. Patients showed signs of inflammation, such as ME and SRF, which were resolved with treatments in some cases. Hyperreflective signals were found in all eyes in the form of nodules or bands across the retina, with the highest frequency of appearance in the ganglion cell layer, inner plexiform layer, photoreceptor layer, and retinal pigment epithelium; such signals increased with the progression of PIOL. Conclusion: SD-OCT may be employed to monitor the progression of PIOL. Hyperreflective signals on OCT may correspond with increase in disease activities, along with other findings such as ME, PED, and SRF.
KW - Primary intraocular lymphoma
KW - Primary retinal lymphoma
KW - Primary vitreoretinal lymphoma
KW - Spectral domain optical coherence tomography (SD-OCT)
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U2 - 10.1186/1869-5760-3-59
DO - 10.1186/1869-5760-3-59
M3 - Article
C2 - 24011267
AN - SCOPUS:84891461697
VL - 3
SP - 1
EP - 8
JO - Journal of Ophthalmic Inflammation and Infection
JF - Journal of Ophthalmic Inflammation and Infection
SN - 1869-5760
IS - 1
M1 - 59
ER -