TY - JOUR
T1 - Loss of 14q and 22q in gastrointestinal stromal tumors (pacemaker cell tumors)
AU - Breiner, Julie A.
AU - Meis-Kindblom, Jeanne
AU - Kindblom, Lars Gunnar
AU - McComb, Erin
AU - Liu, Jian
AU - Nelson, Marilu
AU - Bridge, Julia A.
N1 - Funding Information:
The authors wish to thank William Snyder for his technical assistance and Carla Burke and Kimberly Christian for their expert secretarial assistance. This work was supported in part by grants from the John A. Wiebe Children's Health Care Fund, Children's Hospital, Omaha, Nebraska, and the Nebraska State Department of Health, LB506 and LB595.
PY - 2000/7/15
Y1 - 2000/7/15
N2 - Gastrointestinal stromal tumors (GISTs), also referred to as 'gastrointestinal pacemaker cell tumors (GIPACT)' are mesenchymal neoplasms that are phenotypically similar to the interstitial cells of Cajal (ICC). Cytogenetic studies of this entity are rare and molecular cytogenetic studies utilizing chromosome-specific probes are nonexistent. In the current study, cytogenetic and molecular cytogenetic analysis of 12 histologically and immunohistochemically confirmed GISTs revealed loss of a whole chromosome 14 or region(s) of 14q in 8 tumors evaluated (67%) and loss of a whole chromosome 22 or region(s) of 22q in 8 (67%) patients. Loss of 14q and 22q were observed in histologically benign and malignant GISTs. Structural rearrangements of chromosome 1 were observed in 2 malignant GISTs. These findings indicate that loss of 14q and 22q are nonrandom, early events in GIST tumorigenesis and suggest that tumor suppressor genes responsible for the development of this neoplasm may be located on these chromosomal arms. Copyright (C) 2000 Elsevier Science Inc.
AB - Gastrointestinal stromal tumors (GISTs), also referred to as 'gastrointestinal pacemaker cell tumors (GIPACT)' are mesenchymal neoplasms that are phenotypically similar to the interstitial cells of Cajal (ICC). Cytogenetic studies of this entity are rare and molecular cytogenetic studies utilizing chromosome-specific probes are nonexistent. In the current study, cytogenetic and molecular cytogenetic analysis of 12 histologically and immunohistochemically confirmed GISTs revealed loss of a whole chromosome 14 or region(s) of 14q in 8 tumors evaluated (67%) and loss of a whole chromosome 22 or region(s) of 22q in 8 (67%) patients. Loss of 14q and 22q were observed in histologically benign and malignant GISTs. Structural rearrangements of chromosome 1 were observed in 2 malignant GISTs. These findings indicate that loss of 14q and 22q are nonrandom, early events in GIST tumorigenesis and suggest that tumor suppressor genes responsible for the development of this neoplasm may be located on these chromosomal arms. Copyright (C) 2000 Elsevier Science Inc.
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U2 - 10.1016/S0165-4608(00)00212-0
DO - 10.1016/S0165-4608(00)00212-0
M3 - Article
C2 - 10942800
AN - SCOPUS:0034661189
SN - 0165-4608
VL - 120
SP - 111
EP - 116
JO - Cancer genetics and cytogenetics
JF - Cancer genetics and cytogenetics
IS - 2
ER -