TY - JOUR
T1 - Loss of an X chromosome in aggressive angiomyxoma of female soft parts
T2 - A case report
AU - Kenny-Moynihan, Mary B.
AU - Hagen, Jedd
AU - Richman, Brett
AU - McIntosh, David G.
AU - Bridge, Julia A.
PY - 1996/7/1
Y1 - 1996/7/1
N2 - Cytogenetic analysis of an aggressive angiomyxoma of the vulvar region of a 16-year-old female revealed loss of one X chromosome (45,X,-X) in eight of 20 metaphase cells analyzed. Fluorescence in situ hybridization (FISH) performed on disaggregated cells from paraffin embedded lesional tissue confirmed loss of an X chromosome in 31% of cells. Cytogenetic analysis performed on peripheral blood showed a normal chromosomal complement (46,XX). Thus, loss of one X chromosome appears to be confined to the neoplasm. This anomaly has not been previously described in aggressive angiomyxoma.
AB - Cytogenetic analysis of an aggressive angiomyxoma of the vulvar region of a 16-year-old female revealed loss of one X chromosome (45,X,-X) in eight of 20 metaphase cells analyzed. Fluorescence in situ hybridization (FISH) performed on disaggregated cells from paraffin embedded lesional tissue confirmed loss of an X chromosome in 31% of cells. Cytogenetic analysis performed on peripheral blood showed a normal chromosomal complement (46,XX). Thus, loss of one X chromosome appears to be confined to the neoplasm. This anomaly has not been previously described in aggressive angiomyxoma.
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U2 - 10.1016/0165-4608(95)00350-9
DO - 10.1016/0165-4608(95)00350-9
M3 - Article
C2 - 8689613
AN - SCOPUS:0030200447
SN - 0165-4608
VL - 89
SP - 61
EP - 64
JO - Cancer genetics and cytogenetics
JF - Cancer genetics and cytogenetics
IS - 1
ER -