Low incidence of Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly in Tianjin, northern China

Yi Pan, Bin Meng, Huilai Zhang, Wenfeng Cao, Huaqing Wang, Chengfeng Bi, Fujin Liu, Baocun Sun, Xishan Hao, Weiyun Z. Ai, Kai Fu

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The purpose of this study was to examine the incidence of Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma of the elderly in a representative northern Chinese population. Overall, 212 cases of primary diffuse large B-cell lymphoma were analyzed for EBV-positive status by detection of EBV-encoded RNA using in situ hybridization. Immunophenotypic identity was verified by a streptavidin-biotin peroxidase detection system using the markers CD20, CD3, CD10, BCL6 and MUM1. The prevalence of EBV-positive diffuse large B-cell lymphoma in elderly northern Chinese patients was 3.8% (eight of 212). All eight cases were negative for CD10 and BCL6 immunostaining. The incidence is less frequent than that of southern China and other East-Asian countries. Patients tend to be older, present with a non-germinal center B-cell-like immunophenotype and have a poor outcome.

Original languageEnglish (US)
Pages (from-to)298-303
Number of pages6
JournalLeukemia and Lymphoma
Volume54
Issue number2
DOIs
StatePublished - Feb 2013

Keywords

  • Diffuse large B-cell lymphoma
  • Epstein-Barr virus
  • Immunohistochemistry
  • In situ hybridization
  • Prevalence

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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