Low-level sensory processing in obsessive-compulsive disorder: An evoked potential study

Cary R. Savage; Jeffrey B. Weilburg; Frank H. Duffy; Lee Baer; David M. Shera; Michael A. Jenike

doi:10.1016/0006-3223(94)91255-6

Low-level sensory processing in obsessive-compulsive disorder: An evoked potential study

Cary R. Savage, Jeffrey B. Weilburg, Frank H. Duffy, Lee Baer, David M. Shera, Michael A. Jenike

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

This study used visual and auditory evoked potentials (VEP and AEP) to study low-level sensory processing in a group of 15 unmediated subjects with obsessive-compulsive disorder (OCD) and 30 age-matched, gender-matched, and handedness-matched normal controls. EPs were recorded to flash (VEP) and binaural click (AEP) stimulation. OCD subjects were found to have significantly shorter latencies on N1 and P2 of the AEP, and no differences were found in the VEP. Results indicate abnormal information processing states in OCD during low-level auditory processing, but not during low-level visual processing. Neural generators of the VEP and AEP are briefly reviewed and results are discussed in relation to current neurobiological models of OCD.

Original language	English (US)
Pages (from-to)	247-252
Number of pages	6
Journal	Biological Psychiatry
Volume	35
Issue number	4
DOIs	https://doi.org/10.1016/0006-3223(94)91255-6
State	Published - Feb 15 1994
Externally published	Yes

Keywords

Obsessive-Compulsive Disorder
visual evoked potentials, auditory evoked potentials, sensory processing

ASJC Scopus subject areas

Biological Psychiatry

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10.1016/0006-3223(94)91255-6

Cite this

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title = "Low-level sensory processing in obsessive-compulsive disorder: An evoked potential study",

abstract = "This study used visual and auditory evoked potentials (VEP and AEP) to study low-level sensory processing in a group of 15 unmediated subjects with obsessive-compulsive disorder (OCD) and 30 age-matched, gender-matched, and handedness-matched normal controls. EPs were recorded to flash (VEP) and binaural click (AEP) stimulation. OCD subjects were found to have significantly shorter latencies on N1 and P2 of the AEP, and no differences were found in the VEP. Results indicate abnormal information processing states in OCD during low-level auditory processing, but not during low-level visual processing. Neural generators of the VEP and AEP are briefly reviewed and results are discussed in relation to current neurobiological models of OCD.",

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AU - Savage, Cary R.

AU - Weilburg, Jeffrey B.

AU - Duffy, Frank H.

AU - Baer, Lee

AU - Shera, David M.

AU - Jenike, Michael A.

PY - 1994/2/15

Y1 - 1994/2/15

N2 - This study used visual and auditory evoked potentials (VEP and AEP) to study low-level sensory processing in a group of 15 unmediated subjects with obsessive-compulsive disorder (OCD) and 30 age-matched, gender-matched, and handedness-matched normal controls. EPs were recorded to flash (VEP) and binaural click (AEP) stimulation. OCD subjects were found to have significantly shorter latencies on N1 and P2 of the AEP, and no differences were found in the VEP. Results indicate abnormal information processing states in OCD during low-level auditory processing, but not during low-level visual processing. Neural generators of the VEP and AEP are briefly reviewed and results are discussed in relation to current neurobiological models of OCD.

AB - This study used visual and auditory evoked potentials (VEP and AEP) to study low-level sensory processing in a group of 15 unmediated subjects with obsessive-compulsive disorder (OCD) and 30 age-matched, gender-matched, and handedness-matched normal controls. EPs were recorded to flash (VEP) and binaural click (AEP) stimulation. OCD subjects were found to have significantly shorter latencies on N1 and P2 of the AEP, and no differences were found in the VEP. Results indicate abnormal information processing states in OCD during low-level auditory processing, but not during low-level visual processing. Neural generators of the VEP and AEP are briefly reviewed and results are discussed in relation to current neurobiological models of OCD.

KW - Obsessive-Compulsive Disorder

KW - visual evoked potentials, auditory evoked potentials, sensory processing

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Low-level sensory processing in obsessive-compulsive disorder: An evoked potential study

Abstract

Keywords

ASJC Scopus subject areas

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