Low-level sensory processing in obsessive-compulsive disorder: An evoked potential study

Cary R. Savage, Jeffrey B. Weilburg, Frank H. Duffy, Lee Baer, David M. Shera, Michael A. Jenike

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


This study used visual and auditory evoked potentials (VEP and AEP) to study low-level sensory processing in a group of 15 unmediated subjects with obsessive-compulsive disorder (OCD) and 30 age-matched, gender-matched, and handedness-matched normal controls. EPs were recorded to flash (VEP) and binaural click (AEP) stimulation. OCD subjects were found to have significantly shorter latencies on N1 and P2 of the AEP, and no differences were found in the VEP. Results indicate abnormal information processing states in OCD during low-level auditory processing, but not during low-level visual processing. Neural generators of the VEP and AEP are briefly reviewed and results are discussed in relation to current neurobiological models of OCD.

Original languageEnglish (US)
Pages (from-to)247-252
Number of pages6
JournalBiological Psychiatry
Issue number4
StatePublished - Feb 15 1994
Externally publishedYes


  • Obsessive-Compulsive Disorder
  • visual evoked potentials, auditory evoked potentials, sensory processing

ASJC Scopus subject areas

  • Biological Psychiatry


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