Luminescent platforms for monitoring changes in the solubility of amylin and huntingtin in living cells

Jia Zhao, Quyen Vu, Cliff I. Stains

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Luminescent, cell-based assays capable of monitoring the aggregation potential of the disease-relevant proteins known as amylin (type 2 diabetes) and huntingtin (Huntington's disease) are presented. These sensitive platforms report on the influence of mutations as well as small molecules on protein solubility.

Original languageEnglish (US)
Pages (from-to)2984-2987
Number of pages4
JournalMolecular BioSystems
Volume12
Issue number10
DOIs
StatePublished - 2016

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology

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