Lung albumin content after acid aspiration pulmonary injury

Joseph C. Stothert, L. Jean Weaver, C. James Carrico

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The effects of aspiration of saline and acid on lymph albumin and pulmonary albumin contents were studied. Two radiolabeled species of albumin were used, I125-albumin was allowed to equilibrate while 131I-albumin was injected at Time 0 of the experiment. One percent of total injected albumin was found in the lung in the saline and control groups for both the equilibrated and non-equilibrated varieties of albumin. Seven percent of injected dose of 125I-albumin (equilibrated) was found in the lung after acid aspiration, while 16% of the nonequilibrated 131I-albumin was found. The rate of "wash in" of 131I-albumin was significantly increased in the lymph of acid aspirated animals as compared to controls. These data suggest that the previously demonstrated increase in microvascular permeability after acid aspiration results in an increase in extravascular pulmonary albumin. This effect should greatly alter the local osmotic gradient and result in altered fluid balance.

Original languageEnglish (US)
Pages (from-to)256-261
Number of pages6
JournalJournal of Surgical Research
Volume30
Issue number3
DOIs
StatePublished - Mar 1981
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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