Abstract
Background: The role of oxidative stress remains unclear in the multifactorial pathophysiologic mechanism of lung disease in preterm infants. Aims: The aim of this study was to examine the associations among chronic lung disease (CLD), oxidative stress, and oxygen requirements in preterm infants. Design: Prospective, longitudinal, and correlational design. Subjects: Preterm infants born at <32 weeks’ gestation (N = 31), median gestation of 29.0 weeks (range 24.9–31.7). Measurements: The diagnosis of CLD was obtained from the medical record. Oxidative stress was measured using 8-hydroxydeoxyguanosine (8-OHdG) in the cord blood at birth and urine on Days 1 and 7. Oxygen requirements were measured using fraction of inspired oxygen (FIO2) recorded in the first hour after birth/admission and the average FIO2 during the first 12 hr and 7 days after birth. Descriptive statistics are presented. Comparison analyses were performed using Kruskal–Wallis and Fisher’s exact tests. Results: Infants with CLD (n = 12) had lower gestational age (p =.04) and weight (p =.04) at birth, more days on the ventilator (p =.004), and longer neonatal intensive care unit stay (p =.04) compared to infants without CLD (n = 19). CLD was associated with lower oxidative stress levels (p =.03) and higher oxygen requirements during the first 12 hr (p =.025) and on Day 7 (p =.001). Lower oxidative stress levels on Day 7 were associated with higher oxygen requirements in the first 12 hr (p =.01) and on Day 7 (p =.03). Conclusion: Our results linking CLD and higher oxygen requirements with low oxidative stress contradict previous reports. Findings identify a gap in knowledge for postresuscitation oxygen therapy in preterm infants and expose the role of oxidative stress from inflammation and intermittent hypoxia in the etiology of CLD.
Original language | English (US) |
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Pages (from-to) | 322-330 |
Number of pages | 9 |
Journal | Biological Research for Nursing |
Volume | 18 |
Issue number | 3 |
DOIs | |
State | Published - May 2015 |
Keywords
- chronic lung disease
- oxidative stress
- preterm infant
ASJC Scopus subject areas
- Research and Theory