Luteinizing hormone regulation of inter-organelle communication and fate of the corpus luteum

Emilia Przygrodzka, Michele R. Plewes, John S. Davis

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

The corpus luteum is an endocrine gland that synthesizes the steroid hormone progesterone. luteinizing hormone (LH) is a key luteotropic hormone that stimulates ovulation, luteal development, progesterone biosynthesis, and maintenance of the corpus luteum. Luteotropic and luteolytic factors precisely regulate luteal structure and function; yet, despite recent scientific progress within the past few years, the exact mechanisms remain largely unknown. In the present review, we summarize the recent progress towards understanding cellular changes induced by LH in steroidogenic luteal cells. Herein, we will focus on the effects of LH on inter-organelle communication and steroid biosynthesis, and how LH regulates key protein kinases (i.e., AMPK and MTOR) responsible for controlling steroidogenesis and autophagy in luteal cells.

Original languageEnglish (US)
Article number9972
JournalInternational journal of molecular sciences
Volume22
Issue number18
DOIs
StatePublished - Sep 2021

Keywords

  • Autophagy
  • Cholesterol
  • Corpus luteum
  • LH
  • Lipid droplets
  • Mitochondria
  • Progesterone

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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