Abstract
A technique involving fluorescent protein staining and microfluorometry has been developed for measuring the lymphocyte fluorescent profile (LFP) of peripheral blood lymphocytes. In contrast to normal humans who display a regular bell-shaped curve, the profile from patients with cancer is irregular, showing a bimodal distribution of fluorescence, with a significant population of cells fluorescing at a higher relative intensity. It is suggested that this elevation in protein concentration is due to an immune response to the presence of a neoplasm, and thus this technique may prove to be a useful indicator of malignancy.
Original language | English (US) |
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Pages (from-to) | 357-364 |
Number of pages | 8 |
Journal | Cancer Letters |
Volume | 6 |
Issue number | 6 |
DOIs | |
State | Published - May 1979 |
ASJC Scopus subject areas
- Oncology
- Cancer Research