Lymphomatoid papulosis and progression to T cell lymphoma: An immunophenotypic and genotypic analysis

Douglas S. Harrington, Suzanne W. Braddock, Kathleen S. Blocher, Dennis D. Weisenburger, Warren Sanger, James O. Armitage

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

A 37-year-old white man had untreated lymphomatoid papulosis for 12 years before a submandibular T cell immunoblastic lymphoma developed. A genetic abnormality, composed of extra chromosomal material attached to the short arm of chromosome 9, was detected in the lymphoma tissue but not in the skin. The lymphomatoid papulosis skin lesions did not manifest clonal T cell receptor gene rearrangements, but the submandibular lymphoma tissue was clonal and of T cell lineage. The patient's lymphoma responded well to combination chemotherapy, but the lymphomatoid papulosis remains active.

Original languageEnglish (US)
Pages (from-to)951-957
Number of pages7
JournalJournal of the American Academy of Dermatology
Volume21
Issue number5
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Dermatology

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