Abstract
Validation: Membrane protein structures are sensitive to the environment used for structural characterization. NMR spectra of the full-length M2 proton channel from influenza A were measured directly in E. coli membranes and compared to spectra of the protein in synthetic lipid bilayers. The results demonstrate that these bilayers provide a native-like membrane environment.
Original language | English (US) |
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Pages (from-to) | 8383-8386 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 51 |
Issue number | 33 |
DOIs | |
State | Published - Aug 13 2012 |
Externally published | Yes |
Keywords
- M2 protein
- NMR spectroscopy
- membrane proteins
- structural biology
- structural validation
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)