Macrophage roles following myocardial infarction

Jessica M. Lambert, Elizabeth F. Lopez, Merry L. Lindsey

Research output: Contribution to journalReview articlepeer-review

282 Scopus citations


Following myocardial infarction (MI), circulating blood monocytes respond to chemotactic factors, migrate into the infarcted myocardium, and differentiate into macrophages. At the injury site, macrophages remove necrotic cardiac myocytes and apoptotic neutrophils; secrete cytokines, chemokines, and growth factors; and modulate phases of the angiogenic response. As such, the macrophage is a primary responder cell type that is involved in the regulation of post-MI wound healing at multiple levels. This review summarizes what is currently known about macrophage functions post-MI and borrows literature from other injury and inflammatory models to speculate on additional roles. Basic science and clinical avenues that remain to be explored are also discussed.

Original languageEnglish (US)
Pages (from-to)147-158
Number of pages12
JournalInternational Journal of Cardiology
Issue number2
StatePublished - Nov 12 2008
Externally publishedYes


  • Angiogenesis
  • Fibrosis
  • Left ventricular remodeling
  • Macrophage
  • Matrix metalloproteinases
  • Myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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