Macrophage roles following myocardial infarction

Jessica M. Lambert; Elizabeth F. Lopez; Merry L. Lindsey

doi:10.1016/j.ijcard.2008.04.059

Macrophage roles following myocardial infarction

Jessica M. Lambert, Elizabeth F. Lopez, Merry L. Lindsey

Research output: Contribution to journal › Review article › peer-review

295 Scopus citations

Abstract

Following myocardial infarction (MI), circulating blood monocytes respond to chemotactic factors, migrate into the infarcted myocardium, and differentiate into macrophages. At the injury site, macrophages remove necrotic cardiac myocytes and apoptotic neutrophils; secrete cytokines, chemokines, and growth factors; and modulate phases of the angiogenic response. As such, the macrophage is a primary responder cell type that is involved in the regulation of post-MI wound healing at multiple levels. This review summarizes what is currently known about macrophage functions post-MI and borrows literature from other injury and inflammatory models to speculate on additional roles. Basic science and clinical avenues that remain to be explored are also discussed.

Original language	English (US)
Pages (from-to)	147-158
Number of pages	12
Journal	International Journal of Cardiology
Volume	130
Issue number	2
DOIs	https://doi.org/10.1016/j.ijcard.2008.04.059
State	Published - Nov 12 2008
Externally published	Yes

Keywords

Angiogenesis
Fibrosis
Left ventricular remodeling
Macrophage
Matrix metalloproteinases
Myocardial infarction

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1016/j.ijcard.2008.04.059

Cite this

@article{80dcce2485c94adfb7629476c722a98d,

title = "Macrophage roles following myocardial infarction",

abstract = "Following myocardial infarction (MI), circulating blood monocytes respond to chemotactic factors, migrate into the infarcted myocardium, and differentiate into macrophages. At the injury site, macrophages remove necrotic cardiac myocytes and apoptotic neutrophils; secrete cytokines, chemokines, and growth factors; and modulate phases of the angiogenic response. As such, the macrophage is a primary responder cell type that is involved in the regulation of post-MI wound healing at multiple levels. This review summarizes what is currently known about macrophage functions post-MI and borrows literature from other injury and inflammatory models to speculate on additional roles. Basic science and clinical avenues that remain to be explored are also discussed.",

keywords = "Angiogenesis, Fibrosis, Left ventricular remodeling, Macrophage, Matrix metalloproteinases, Myocardial infarction",

author = "Lambert, {Jessica M.} and Lopez, {Elizabeth F.} and Lindsey, {Merry L.}",

note = "Funding Information: The authors gratefully acknowledge support from the National Institutes of Health (National Heart Lung and Blood Institute, HL-75360). JML was a recipient of the UTHSCSA Medical Student Research Stipend Program and EFL was the recipient of a NIH research supplement (HL-75360S1).",

year = "2008",

month = nov,

day = "12",

doi = "10.1016/j.ijcard.2008.04.059",

language = "English (US)",

volume = "130",

pages = "147--158",

journal = "International Journal of Cardiology",

issn = "0167-5273",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Macrophage roles following myocardial infarction

AU - Lambert, Jessica M.

AU - Lopez, Elizabeth F.

AU - Lindsey, Merry L.

N1 - Funding Information: The authors gratefully acknowledge support from the National Institutes of Health (National Heart Lung and Blood Institute, HL-75360). JML was a recipient of the UTHSCSA Medical Student Research Stipend Program and EFL was the recipient of a NIH research supplement (HL-75360S1).

PY - 2008/11/12

Y1 - 2008/11/12

N2 - Following myocardial infarction (MI), circulating blood monocytes respond to chemotactic factors, migrate into the infarcted myocardium, and differentiate into macrophages. At the injury site, macrophages remove necrotic cardiac myocytes and apoptotic neutrophils; secrete cytokines, chemokines, and growth factors; and modulate phases of the angiogenic response. As such, the macrophage is a primary responder cell type that is involved in the regulation of post-MI wound healing at multiple levels. This review summarizes what is currently known about macrophage functions post-MI and borrows literature from other injury and inflammatory models to speculate on additional roles. Basic science and clinical avenues that remain to be explored are also discussed.

AB - Following myocardial infarction (MI), circulating blood monocytes respond to chemotactic factors, migrate into the infarcted myocardium, and differentiate into macrophages. At the injury site, macrophages remove necrotic cardiac myocytes and apoptotic neutrophils; secrete cytokines, chemokines, and growth factors; and modulate phases of the angiogenic response. As such, the macrophage is a primary responder cell type that is involved in the regulation of post-MI wound healing at multiple levels. This review summarizes what is currently known about macrophage functions post-MI and borrows literature from other injury and inflammatory models to speculate on additional roles. Basic science and clinical avenues that remain to be explored are also discussed.

KW - Angiogenesis

KW - Fibrosis

KW - Left ventricular remodeling

KW - Macrophage

KW - Matrix metalloproteinases

KW - Myocardial infarction

UR - http://www.scopus.com/inward/record.url?scp=54949106928&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54949106928&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2008.04.059

DO - 10.1016/j.ijcard.2008.04.059

M3 - Review article

C2 - 18656272

AN - SCOPUS:54949106928

SN - 0167-5273

VL - 130

SP - 147

EP - 158

JO - International Journal of Cardiology

JF - International Journal of Cardiology

IS - 2

ER -

Macrophage roles following myocardial infarction

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this