Macrophages, microglia and dendritic cell function

James Hilaire, Howard E. Gendelman

Research output: Chapter in Book/Report/Conference proceedingChapter


Mononuclear phagocytes (MP; monocytes, macrophages, microglia and dendritic cells) are joined together based on common function and phenotypic properties. In regards to phagocytoic, interacellular killing, secretory, antigen presentation and mobility properties differentiating the cell types can be difficult. Ontogeny, locale and modest phenotype differences underlie differences. Similarities abound in innate immunity and protection of a steady-state homeostatic environment and engaging inflammatory responses that direct surveillance and clearance responses. A clear benefit of spanning tissue origins and species differences underlies the importance of these cells that serve as the first line of immune defense.

Original languageEnglish (US)
Title of host publicationNeuroimmune Pharmacology
PublisherSpringer International Publishing
Number of pages14
ISBN (Electronic)9783319440224
ISBN (Print)9783319440200
StatePublished - Jan 1 2016


  • Dendritic cells
  • Macrophages
  • Major histocompatibility
  • Microglia
  • Mononuclear phagocytes
  • Multiple sclerosis
  • Neurodegeneration
  • Neuroprotection
  • Pathogen-associated patterns
  • Progenitor cells
  • Reactive oxygen species
  • Toll-like receptors

ASJC Scopus subject areas

  • General Medicine
  • General Immunology and Microbiology
  • General Neuroscience
  • Pharmacology, Toxicology and Pharmaceutics(all)


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