Macrophages, microglia and dendritic cell function

Mononuclear phagocytes (MP; monocytes, macrophages, microglia and dendritic cells) are joined together based on common function and phenotypic properties. In regards to phagocytoic, interacellular killing, secretory, antigen presentation and mobility properties differentiating the cell types can be difficult. Ontogeny, locale and modest phenotype differences underlie differences. Similarities abound in innate immunity and protection of a steady-state homeostatic environment and engaging inflammatory responses that direct surveillance and clearance responses. A clear benefit of spanning tissue origins and species differences underlies the importance of these cells that serve as the first line of immune defense.