Macular Degeneration

W. B. Thoreson, E. Margalit

Research output: Chapter in Book/Report/Conference proceedingChapter


Macula r degeneration is a loss of central vision due to progressive degeneration of the macular region of the retina. It is estimated that 25% of those 75 years or older exhibit some age-related macular degeneration (ARMD). Juvenile forms, such as Stargardt's disease, can also strike younger individuals. ARMD can present as a wet (exudative) form involving choroidal neovascularization or a dry (nonexudative) form. Complement-related genes confer susceptibility suggesting that immune-mediated inflammatory responses contribute to ARMD. Oxidative damage to the retinal pigment epithelium may also contribute. Intravitreal injections of anti-vascular endothelial growth factor agents are the primary therapy for wet ARMD.

Original languageEnglish (US)
Title of host publicationReference Module in Biomedical Research
PublisherElsevier Inc.
ISBN (Print)9780128012383
StatePublished - Dec 15 2014


  • Age-related macular degeneration (ARMD)
  • Choroidal neovascularization
  • Complement factor
  • Drusen
  • Fovea
  • Photoreceptors
  • Retina
  • Retinal degeneration
  • Retinal pigment epithelium (RPE)
  • Scotoma
  • Stargardt's disease
  • Vascular endothelial growth factor (VEGF)
  • Vision loss

ASJC Scopus subject areas

  • General Medicine


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