Macular Degeneration

W. B. Thoreson; E. Margalit

doi:10.1016/B978-0-12-801238-3.05127-8

Macular Degeneration

W. B. Thoreson, E. Margalit

Ophthalmology and Visual Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Macula r degeneration is a loss of central vision due to progressive degeneration of the macular region of the retina. It is estimated that 25% of those 75 years or older exhibit some age-related macular degeneration (ARMD). Juvenile forms, such as Stargardt's disease, can also strike younger individuals. ARMD can present as a wet (exudative) form involving choroidal neovascularization or a dry (nonexudative) form. Complement-related genes confer susceptibility suggesting that immune-mediated inflammatory responses contribute to ARMD. Oxidative damage to the retinal pigment epithelium may also contribute. Intravitreal injections of anti-vascular endothelial growth factor agents are the primary therapy for wet ARMD.

Original language	English (US)
Title of host publication	Reference Module in Biomedical Research
Publisher	Elsevier Inc.
ISBN (Print)	9780128012383
DOIs	https://doi.org/10.1016/B978-0-12-801238-3.05127-8
State	Published - Dec 15 2014

Keywords

Age-related macular degeneration (ARMD)
Choroidal neovascularization
Complement factor
Drusen
Fovea
Photoreceptors
Retina
Retinal degeneration
Retinal pigment epithelium (RPE)
Scotoma
Stargardt's disease
Vascular endothelial growth factor (VEGF)
Vision loss

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1016/B978-0-12-801238-3.05127-8

Cite this

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title = "Macular Degeneration",

abstract = "Macula r degeneration is a loss of central vision due to progressive degeneration of the macular region of the retina. It is estimated that 25% of those 75 years or older exhibit some age-related macular degeneration (ARMD). Juvenile forms, such as Stargardt's disease, can also strike younger individuals. ARMD can present as a wet (exudative) form involving choroidal neovascularization or a dry (nonexudative) form. Complement-related genes confer susceptibility suggesting that immune-mediated inflammatory responses contribute to ARMD. Oxidative damage to the retinal pigment epithelium may also contribute. Intravitreal injections of anti-vascular endothelial growth factor agents are the primary therapy for wet ARMD.",

keywords = "Age-related macular degeneration (ARMD), Choroidal neovascularization, Complement factor, Drusen, Fovea, Photoreceptors, Retina, Retinal degeneration, Retinal pigment epithelium (RPE), Scotoma, Stargardt's disease, Vascular endothelial growth factor (VEGF), Vision loss",

author = "Thoreson, {W. B.} and E. Margalit",

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T1 - Macular Degeneration

AU - Thoreson, W. B.

AU - Margalit, E.

PY - 2014/12/15

Y1 - 2014/12/15

N2 - Macula r degeneration is a loss of central vision due to progressive degeneration of the macular region of the retina. It is estimated that 25% of those 75 years or older exhibit some age-related macular degeneration (ARMD). Juvenile forms, such as Stargardt's disease, can also strike younger individuals. ARMD can present as a wet (exudative) form involving choroidal neovascularization or a dry (nonexudative) form. Complement-related genes confer susceptibility suggesting that immune-mediated inflammatory responses contribute to ARMD. Oxidative damage to the retinal pigment epithelium may also contribute. Intravitreal injections of anti-vascular endothelial growth factor agents are the primary therapy for wet ARMD.

AB - Macula r degeneration is a loss of central vision due to progressive degeneration of the macular region of the retina. It is estimated that 25% of those 75 years or older exhibit some age-related macular degeneration (ARMD). Juvenile forms, such as Stargardt's disease, can also strike younger individuals. ARMD can present as a wet (exudative) form involving choroidal neovascularization or a dry (nonexudative) form. Complement-related genes confer susceptibility suggesting that immune-mediated inflammatory responses contribute to ARMD. Oxidative damage to the retinal pigment epithelium may also contribute. Intravitreal injections of anti-vascular endothelial growth factor agents are the primary therapy for wet ARMD.

KW - Age-related macular degeneration (ARMD)

KW - Choroidal neovascularization

KW - Complement factor

KW - Drusen

KW - Fovea

KW - Photoreceptors

KW - Retina

KW - Retinal degeneration

KW - Retinal pigment epithelium (RPE)

KW - Scotoma

KW - Stargardt's disease

KW - Vascular endothelial growth factor (VEGF)

KW - Vision loss

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SN - 9780128012383

BT - Reference Module in Biomedical Research

PB - Elsevier Inc.

ER -

Macular Degeneration

Abstract

Keywords

ASJC Scopus subject areas

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