Magnetically responsive polymeric microparticles for oral delivery of protein drugs

Jianjun Cheng, Benjamin A. Teply, Seok Yoon Jeong, Christopher H. Yim, Dennis Ho, Ines Sherifi, Sangyong Jon, Omid C. Farokhzad, Ali Khademhosseini, Robert S. Langer

Research output: Contribution to journalArticle

105 Scopus citations

Abstract

Purpose. Protein drugs cannot be delivered efficiently through oral routes. To address this challenge, we evaluated the effect of prolonged gastrointestinal transit on the bioavailability of insulin carried by magnetically responsive microparticles in the presence of an external magnetic field. Methods. Magnetite nanocrystals and insulin were coencapsulated into poly(lactide-co-glycolide) (PLGA) microparticles and their effects on hypoglycemia were evaluated in mice in the presence of a circumferentially applied external magnetic field. Results. A single administration of 100 U/kg of insulin-magnetite-PLGA microparticles to fasted mice resulted in a reduction of blood glucose levels of up to 43.8% in the presence of an external magnetic field for 20 h (bioavailability = 2.77 ± 0.46 and 0.87 ± 0.29% based on glucose and ELISA assay, respectively), significantly higher than similarly dosed mice without a magnetic field (bioavailability = 0.66 ± 0.56 and 0.30 ± 0.06%, based on glucose and ELISA assay, respectively). Conclusions. A substantially improved hypoglycemic effect was observed in mice that were orally administered with insulin-magnetite-PLGA microparticles in the presence of an external magnetic field, suggesting that magnetic force can be used to improve the efficiency of orally delivered protein therapeutics.

Original languageEnglish (US)
Pages (from-to)557-564
Number of pages8
JournalPharmaceutical Research
Volume23
Issue number3
DOIs
StatePublished - Mar 2006

Keywords

  • Insulin
  • Magnetic particles
  • Microparticles
  • Oral delivery
  • Protein drugs

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Magnetically responsive polymeric microparticles for oral delivery of protein drugs'. Together they form a unique fingerprint.

  • Cite this

    Cheng, J., Teply, B. A., Jeong, S. Y., Yim, C. H., Ho, D., Sherifi, I., Jon, S., Farokhzad, O. C., Khademhosseini, A., & Langer, R. S. (2006). Magnetically responsive polymeric microparticles for oral delivery of protein drugs. Pharmaceutical Research, 23(3), 557-564. https://doi.org/10.1007/s11095-005-9444-5