TY - JOUR
T1 - Magnetite nanoparticles for medical MR imaging
AU - Stephen, Zachary R.
AU - Kievit, Forrest M.
AU - Zhang, Miqin
N1 - Funding Information:
We acknowledge the support of the NIH Grants R01CA134213, R01EB006043, and T32CA138312 .
PY - 2011
Y1 - 2011
N2 - Nanotechnology has given scientists new tools for the development of advanced materials for the detection and diagnosis of disease. In particular, superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively investigated as novel magnetic resonance imaging (MRI) contrast agents due to a combination of favorable superparamagnetic properties, biodegradability, and surface properties. This review discusses the basics of MR imaging, the origin of SPION's unique magnetic properties, recent developments in MRI acquisition methods for detection of SPIONs, synthesis and post-synthesis processes that improve SPION's imaging characteristics, and the outlook of the translational potential of SPIONs.
AB - Nanotechnology has given scientists new tools for the development of advanced materials for the detection and diagnosis of disease. In particular, superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively investigated as novel magnetic resonance imaging (MRI) contrast agents due to a combination of favorable superparamagnetic properties, biodegradability, and surface properties. This review discusses the basics of MR imaging, the origin of SPION's unique magnetic properties, recent developments in MRI acquisition methods for detection of SPIONs, synthesis and post-synthesis processes that improve SPION's imaging characteristics, and the outlook of the translational potential of SPIONs.
UR - http://www.scopus.com/inward/record.url?scp=79960185277&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960185277&partnerID=8YFLogxK
U2 - 10.1016/S1369-7021(11)70163-8
DO - 10.1016/S1369-7021(11)70163-8
M3 - Article
AN - SCOPUS:79960185277
VL - 14
SP - 330
EP - 338
JO - Materials Today
JF - Materials Today
SN - 1369-7021
IS - 7-8
ER -