Magnetite nanoparticles for medical MR imaging

Zachary R. Stephen; Forrest M. Kievit; Miqin Zhang

doi:10.1016/S1369-7021(11)70163-8

Magnetite nanoparticles for medical MR imaging

Zachary R. Stephen, Forrest M. Kievit, Miqin Zhang

Research output: Contribution to journal › Article › peer-review

240 Scopus citations

Abstract

Nanotechnology has given scientists new tools for the development of advanced materials for the detection and diagnosis of disease. In particular, superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively investigated as novel magnetic resonance imaging (MRI) contrast agents due to a combination of favorable superparamagnetic properties, biodegradability, and surface properties. This review discusses the basics of MR imaging, the origin of SPION's unique magnetic properties, recent developments in MRI acquisition methods for detection of SPIONs, synthesis and post-synthesis processes that improve SPION's imaging characteristics, and the outlook of the translational potential of SPIONs.

Original language	English (US)
Pages (from-to)	330-338
Number of pages	9
Journal	Materials Today
Volume	14
Issue number	7-8
DOIs	https://doi.org/10.1016/S1369-7021(11)70163-8
State	Published - 2011
Externally published	Yes

ASJC Scopus subject areas

Materials Science(all)
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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title = "Magnetite nanoparticles for medical MR imaging",

abstract = "Nanotechnology has given scientists new tools for the development of advanced materials for the detection and diagnosis of disease. In particular, superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively investigated as novel magnetic resonance imaging (MRI) contrast agents due to a combination of favorable superparamagnetic properties, biodegradability, and surface properties. This review discusses the basics of MR imaging, the origin of SPION's unique magnetic properties, recent developments in MRI acquisition methods for detection of SPIONs, synthesis and post-synthesis processes that improve SPION's imaging characteristics, and the outlook of the translational potential of SPIONs.",

author = "Stephen, {Zachary R.} and Kievit, {Forrest M.} and Miqin Zhang",

note = "Funding Information: We acknowledge the support of the NIH Grants R01CA134213, R01EB006043, and T32CA138312 . ",

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T1 - Magnetite nanoparticles for medical MR imaging

AU - Stephen, Zachary R.

AU - Kievit, Forrest M.

AU - Zhang, Miqin

N1 - Funding Information: We acknowledge the support of the NIH Grants R01CA134213, R01EB006043, and T32CA138312 .

PY - 2011

Y1 - 2011

N2 - Nanotechnology has given scientists new tools for the development of advanced materials for the detection and diagnosis of disease. In particular, superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively investigated as novel magnetic resonance imaging (MRI) contrast agents due to a combination of favorable superparamagnetic properties, biodegradability, and surface properties. This review discusses the basics of MR imaging, the origin of SPION's unique magnetic properties, recent developments in MRI acquisition methods for detection of SPIONs, synthesis and post-synthesis processes that improve SPION's imaging characteristics, and the outlook of the translational potential of SPIONs.

AB - Nanotechnology has given scientists new tools for the development of advanced materials for the detection and diagnosis of disease. In particular, superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively investigated as novel magnetic resonance imaging (MRI) contrast agents due to a combination of favorable superparamagnetic properties, biodegradability, and surface properties. This review discusses the basics of MR imaging, the origin of SPION's unique magnetic properties, recent developments in MRI acquisition methods for detection of SPIONs, synthesis and post-synthesis processes that improve SPION's imaging characteristics, and the outlook of the translational potential of SPIONs.

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