Magnetite nanoparticles for medical MR imaging

Zachary R. Stephen, Forrest M. Kievit, Miqin Zhang

Research output: Contribution to journalArticlepeer-review

356 Scopus citations


Nanotechnology has given scientists new tools for the development of advanced materials for the detection and diagnosis of disease. In particular, superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively investigated as novel magnetic resonance imaging (MRI) contrast agents due to a combination of favorable superparamagnetic properties, biodegradability, and surface properties. This review discusses the basics of MR imaging, the origin of SPION's unique magnetic properties, recent developments in MRI acquisition methods for detection of SPIONs, synthesis and post-synthesis processes that improve SPION's imaging characteristics, and the outlook of the translational potential of SPIONs.

Original languageEnglish (US)
Pages (from-to)330-338
Number of pages9
JournalMaterials Today
Issue number7-8
StatePublished - 2011
Externally publishedYes

ASJC Scopus subject areas

  • General Materials Science
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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