Magnetite-PLGA microparticles for oral delivery of insulin

Jianjun Cheng, Christopher H. Yim, Benjamin A. Teply, Dennis Ho, Omid C. Farokhzad, Robert S. Langer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Magnetic responsive particles were designed for use in oral delivery of insulin. Magnetite nanoparticles (12 nm average size) were synthesized and co-encapsulated with insulin into poly(lactide-co-glycolide) (PLGA) microparticles (4.6 ± 2.2 μm average particle size) through the double-emulsion method, The spherical structures of resulting microparticles were well maintained at magnetite content 5 wt % or less. Mice were gavaged with 125I-insulin-magnetite-PLGA microparticles and a circumferential trans-abdominal magnetic field was applied forty minutes after administration to retard the transit of the microparticles in the intestinal tract. As control, mice were similarly dosed without the subsequent trans-abdominal magnetic field. Mice were sacrificed, and the intestinal radioactivity was 101% and 145% higher in treated mice versus the control at 6 h and 12 h, respectively. A single administration of 50 unit/kg Humulin R-magnetite-PLGA microparticles to the fasted mice resulted in 66% reduction of blood glucose level in the presence of external magnetic field at 12 h, compared to 27% reduction in the absence of magnetic field,

Original languageEnglish (US)
Title of host publicationBiological and Bio-Inspired Materials and Devices
Pages109-114
Number of pages6
StatePublished - Dec 1 2005
Event2005 MRS Spring Meeting - San Francisco, CA, United States
Duration: Mar 28 2005Apr 1 2005

Publication series

NameMaterials Research Society Symposium Proceedings
Volume873
ISSN (Print)0272-9172

Other

Other2005 MRS Spring Meeting
CountryUnited States
CitySan Francisco, CA
Period3/28/054/1/05

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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  • Cite this

    Cheng, J., Yim, C. H., Teply, B. A., Ho, D., Farokhzad, O. C., & Langer, R. S. (2005). Magnetite-PLGA microparticles for oral delivery of insulin. In Biological and Bio-Inspired Materials and Devices (pp. 109-114). (Materials Research Society Symposium Proceedings; Vol. 873).