TY - JOUR
T1 - Magnetoencephalography reveals altered auditory information processing in youth with obsessive-compulsive disorder
AU - Korostenskaja, Milena
AU - Harris, Elana
AU - Giovanetti, Cathy
AU - Horn, Paul
AU - Wang, Yingying
AU - Rose, Douglas
AU - Fujiwara, Hisako
AU - Xiang, Jing
N1 - Funding Information:
The study was partially supported by a Trustee Grant to Dr. Jing Xiang from Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA, and by internal divisional support to Dr. Elana Harris. We would like to thank Dr. David Brown (Audiological Research, Cincinnati Children's Hospital and University of Cincinnati College of Medicine) for providing references to our manuscript. We also would like to express our gratitude to Nat Hemasilpin and Elijah Kirtman for their technical assistance in MEG recordings.
PY - 2013/5/30
Y1 - 2013/5/30
N2 - Patients with obsessive-compulsive disorder (OCD) often report sensory intolerances which may lead to significant functional impairment. This study used auditory evoked fields (AEFs) to address the question of whether neural correlates of sensory auditory information processing differ in youth with OCD compared with healthy comparison subjects (HCS). AEFs, recorded with a whole head 275-channel magnetoencephalography system, were elicited in response to binaural auditory stimuli from 10 pediatric subjects with OCD (ages 8-13, mean 11 years, 6 males) and 10 age- and gender-matched HCS. Three major neuromagnetic responses were studied: M70 (60-80 ms), M100 (90-120 ms), and M150 (130-190. ms). When compared with HCS, subjects with OCD demonstrated delayed latency of the M100 response. In subjects with OCD the amplitude of the M100 and M150 responses was significantly greater in the right hemisphere compared with the left hemisphere. Current results suggest that when compared with HCS, subjects with OCD have altered auditory information processing, evident from the delayed latency of the M100 response, which is thought to be associated with the encoding of physical stimulus characteristics. Interhemispheric asymmetry with increased M100 and M150 amplitudes over the right hemisphere compared with the left hemisphere was found in young OCD subjects. These results should be interpreted with caution due to the high variability rate of responses in both HCS and OCD subjects, as well as the possible effect of medication in OCD subjects.
AB - Patients with obsessive-compulsive disorder (OCD) often report sensory intolerances which may lead to significant functional impairment. This study used auditory evoked fields (AEFs) to address the question of whether neural correlates of sensory auditory information processing differ in youth with OCD compared with healthy comparison subjects (HCS). AEFs, recorded with a whole head 275-channel magnetoencephalography system, were elicited in response to binaural auditory stimuli from 10 pediatric subjects with OCD (ages 8-13, mean 11 years, 6 males) and 10 age- and gender-matched HCS. Three major neuromagnetic responses were studied: M70 (60-80 ms), M100 (90-120 ms), and M150 (130-190. ms). When compared with HCS, subjects with OCD demonstrated delayed latency of the M100 response. In subjects with OCD the amplitude of the M100 and M150 responses was significantly greater in the right hemisphere compared with the left hemisphere. Current results suggest that when compared with HCS, subjects with OCD have altered auditory information processing, evident from the delayed latency of the M100 response, which is thought to be associated with the encoding of physical stimulus characteristics. Interhemispheric asymmetry with increased M100 and M150 amplitudes over the right hemisphere compared with the left hemisphere was found in young OCD subjects. These results should be interpreted with caution due to the high variability rate of responses in both HCS and OCD subjects, as well as the possible effect of medication in OCD subjects.
KW - Auditory evoked fields (AEFs)
KW - Auditory evoked potentials (AEPs)
KW - Event-related fields (ERFs)
KW - Event-related potentials (ERPs)
KW - M100
KW - Obsessive-compulsive disorder (OCD)
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UR - http://www.scopus.com/inward/citedby.url?scp=84876790230&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2012.11.011
DO - 10.1016/j.pscychresns.2012.11.011
M3 - Article
C2 - 23545237
AN - SCOPUS:84876790230
SN - 0925-4927
VL - 212
SP - 132
EP - 140
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 2
ER -