Maintaining K+ balance on the low-Na+, high-K+ diet

Ryan J. Cornelius, Bangchen Wang, Jun Wang-France, Steven C. Sansom

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


A low-Na+, high-K+diet (LNaHK) is considered a healthier alternative to the “Western” high-Na+ diet. Because the mechanism for K+ secretion involves Na+ reabsorptive exchange for secreted K+ in the distal nephron, it is not understood how K+ is eliminated with such low Na+ intake. Animals on a LNaHK diet produce an alkaline load, high urinary flows, and markedly elevated plasma ANG II and aldosterone levels to maintain their K+ balance. Recent studies have revealed a potential mechanism involving the actions of alkalosis, urinary flow, elevated ANG II, and aldosterone on two types of K+ channels, renal outer medullary K+ and large-conductance K+ channels, located in principal and intercalated cells. Here, we review these recent advances.

Original languageEnglish (US)
Pages (from-to)F581-F595
JournalAmerican Journal of Physiology - Renal Physiology
Issue number7
StatePublished - Apr 1 2016


  • Angiotensin II
  • Epithelial Na channel
  • Largeconductance K channel
  • Na-Clcotransporter
  • Renal outer medullary K channel

ASJC Scopus subject areas

  • Physiology
  • Urology


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