Maintaining K+ balance on the low-Na+, high-K+ diet

Ryan J. Cornelius, Bangchen Wang, Jun Wang-France, Steven C. Sansom

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

A low-Na+, high-K+diet (LNaHK) is considered a healthier alternative to the “Western” high-Na+ diet. Because the mechanism for K+ secretion involves Na+ reabsorptive exchange for secreted K+ in the distal nephron, it is not understood how K+ is eliminated with such low Na+ intake. Animals on a LNaHK diet produce an alkaline load, high urinary flows, and markedly elevated plasma ANG II and aldosterone levels to maintain their K+ balance. Recent studies have revealed a potential mechanism involving the actions of alkalosis, urinary flow, elevated ANG II, and aldosterone on two types of K+ channels, renal outer medullary K+ and large-conductance K+ channels, located in principal and intercalated cells. Here, we review these recent advances.

Original languageEnglish (US)
Pages (from-to)F581-F595
JournalAmerican Journal of Physiology - Renal Physiology
Volume310
Issue number7
DOIs
StatePublished - Apr 1 2016

Keywords

  • Angiotensin II
  • Epithelial Na channel
  • Largeconductance K channel
  • Na-Clcotransporter
  • Renal outer medullary K channel

ASJC Scopus subject areas

  • Physiology
  • Urology

Fingerprint Dive into the research topics of 'Maintaining K<sup>+</sup> balance on the low-Na<sup>+</sup>, high-K<sup>+</sup> diet'. Together they form a unique fingerprint.

  • Cite this