Maintenance of CTCF- and Transcription Factor-Mediated Interactions from the Gametes to the Early Mouse Embryo

Yoon Hee Jung; Isaac Kremsky; Hannah B. Gold; M. Jordan Rowley; Kanchana Punyawai; Alyx Buonanotte; Xiaowen Lyu; Brianna J. Bixler; Anthony W.S. Chan; Victor G. Corces

doi:10.1016/j.molcel.2019.04.014

Maintenance of CTCF- and Transcription Factor-Mediated Interactions from the Gametes to the Early Mouse Embryo

Yoon Hee Jung, Isaac Kremsky, Hannah B. Gold, M. Jordan Rowley, Kanchana Punyawai, Alyx Buonanotte, Xiaowen Lyu, Brianna J. Bixler, Anthony W.S. Chan, Victor G. Corces

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

Jung et al. show that sperm and oocyte promoters and enhancers contain ATAC-seq accessible sites suggesting the presence of Pol II, Foxa1, ERα, and AR. Accessibility in gametes persists in early embryos. Interactions mediated by CTCF in gametes are inherited from each parent and become the same in 8-cell embryos.

Original language	English (US)
Pages (from-to)	154-171.e5
Journal	Molecular Cell
Volume	75
Issue number	1
DOIs	https://doi.org/10.1016/j.molcel.2019.04.014
State	Published - Jul 11 2019
Externally published	Yes

Keywords

Foxa1
androgen
chromatin
development
enhancer
estrogen
fertilization
oocyte
sperm
transcription

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2019.04.014

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title = "Maintenance of CTCF- and Transcription Factor-Mediated Interactions from the Gametes to the Early Mouse Embryo",

abstract = "Jung et al. show that sperm and oocyte promoters and enhancers contain ATAC-seq accessible sites suggesting the presence of Pol II, Foxa1, ERα, and AR. Accessibility in gametes persists in early embryos. Interactions mediated by CTCF in gametes are inherited from each parent and become the same in 8-cell embryos.",

keywords = "Foxa1, androgen, chromatin, development, enhancer, estrogen, fertilization, oocyte, sperm, transcription",

author = "Jung, {Yoon Hee} and Isaac Kremsky and Gold, {Hannah B.} and Rowley, {M. Jordan} and Kanchana Punyawai and Alyx Buonanotte and Xiaowen Lyu and Bixler, {Brianna J.} and Chan, {Anthony W.S.} and Corces, {Victor G.}",

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doi = "10.1016/j.molcel.2019.04.014",

language = "English (US)",

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T1 - Maintenance of CTCF- and Transcription Factor-Mediated Interactions from the Gametes to the Early Mouse Embryo

AU - Jung, Yoon Hee

AU - Kremsky, Isaac

AU - Gold, Hannah B.

AU - Rowley, M. Jordan

AU - Punyawai, Kanchana

AU - Buonanotte, Alyx

AU - Lyu, Xiaowen

AU - Bixler, Brianna J.

AU - Chan, Anthony W.S.

AU - Corces, Victor G.

PY - 2019/7/11

Y1 - 2019/7/11

N2 - Jung et al. show that sperm and oocyte promoters and enhancers contain ATAC-seq accessible sites suggesting the presence of Pol II, Foxa1, ERα, and AR. Accessibility in gametes persists in early embryos. Interactions mediated by CTCF in gametes are inherited from each parent and become the same in 8-cell embryos.

AB - Jung et al. show that sperm and oocyte promoters and enhancers contain ATAC-seq accessible sites suggesting the presence of Pol II, Foxa1, ERα, and AR. Accessibility in gametes persists in early embryos. Interactions mediated by CTCF in gametes are inherited from each parent and become the same in 8-cell embryos.

KW - Foxa1

KW - androgen

KW - chromatin

KW - development

KW - enhancer

KW - estrogen

KW - fertilization

KW - oocyte

KW - sperm

KW - transcription

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Maintenance of CTCF- and Transcription Factor-Mediated Interactions from the Gametes to the Early Mouse Embryo

Abstract

Keywords

ASJC Scopus subject areas

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