Abstract
Jung et al. show that sperm and oocyte promoters and enhancers contain ATAC-seq accessible sites suggesting the presence of Pol II, Foxa1, ERα, and AR. Accessibility in gametes persists in early embryos. Interactions mediated by CTCF in gametes are inherited from each parent and become the same in 8-cell embryos.
Original language | English (US) |
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Pages (from-to) | 154-171.e5 |
Journal | Molecular Cell |
Volume | 75 |
Issue number | 1 |
DOIs | |
State | Published - Jul 11 2019 |
Externally published | Yes |
Keywords
- Foxa1
- androgen
- chromatin
- development
- enhancer
- estrogen
- fertilization
- oocyte
- sperm
- transcription
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology