Maintenance of CTCF- and Transcription Factor-Mediated Interactions from the Gametes to the Early Mouse Embryo

Yoon Hee Jung, Isaac Kremsky, Hannah B. Gold, M. Jordan Rowley, Kanchana Punyawai, Alyx Buonanotte, Xiaowen Lyu, Brianna J. Bixler, Anthony W.S. Chan, Victor G. Corces

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Jung et al. show that sperm and oocyte promoters and enhancers contain ATAC-seq accessible sites suggesting the presence of Pol II, Foxa1, ERα, and AR. Accessibility in gametes persists in early embryos. Interactions mediated by CTCF in gametes are inherited from each parent and become the same in 8-cell embryos.

Original languageEnglish (US)
Pages (from-to)154-171.e5
JournalMolecular Cell
Volume75
Issue number1
DOIs
StatePublished - Jul 11 2019

Keywords

  • Foxa1
  • androgen
  • chromatin
  • development
  • enhancer
  • estrogen
  • fertilization
  • oocyte
  • sperm
  • transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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