Malignant paraganglioma of the bladder: A case report and review of the literature

Erin E. Quist, Barry M. Javadzadeh, Eric Johannesen, Sonny L. Johansson, Subodh M. Lele, Jessica A. Kozel

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Although paragangliomas of the bladder are uncommon, malignant paragangliomas of this anatomic site are exceedingly rare, with a mere 37 previously reported cases. We report the case of a 58-year-old man with a malignant paraganglioma of the bladder who sought care secondary to gross hematuria; however, misdiagnosis of this tumor resulted in hypertensive crisis during cystoprostatectomy. Not only does this case present a unique malignant paraganglioma of the bladder, but also it discusses the clinical ramifications when misdiagnosed. Like pheochromocytomas, extra-adrenal paragangliomas can manifest with similar sympathetic stimulation; this becomes a serious complication for clinicians resecting these tumors in unusual locations without proper histologic diagnosis. Additionally, we discuss the unique clinical and pathologic findings of our patient and comprehensively review the previously published cases comparing clinical and pathologic features. Several interesting findings are identified including average age at diagnosis, gender predilection, presenting symptoms, size at diagnosis, and common sites of metastasis.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalPathology Research and Practice
Volume211
Issue number2
DOIs
StatePublished - Feb 1 2015

Keywords

  • Malignant paraganglioma
  • Paraganglioma
  • Paraganglioma of urinary bladder

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

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