TY - JOUR
T1 - Management of immune cytopenias in patients with systemic lupus erythematosus - Old and new
AU - Newman, Kam
AU - Owlia, Mohammad Bagher
AU - El-Hemaidi, Ihab
AU - Akhtari, Mojtaba
PY - 2013/5
Y1 - 2013/5
N2 - There are various immune cytopenias associated with systemic lupus erythematosus (SLE). The most common one is anemia; however, there are different etiologies for the anemia caused by SLE. Anemia could be due to chronic disease, secondary to renal insufficiency, blood loss, drug induced or autoimmune hemolysis. There are other very rare causes of anemia secondary to SLE which include red cell aplasia, aplastic anemia, and microangiopathic hemolytic anemia. Treatment of the anemia would be according to the cause. Leukopenia, neutropenia, and lymphopenia are hematologic complications associated with SLE, and in majority of cases no treatment is required. Thrombocytopenia is one of the complications of SLE and is usually treated by steroids. However, there are significant numbers of patients which will either not respond to or relapse after treatment. This article summarizes immune cytopenias seen in patients with SLE, and it also discusses management of these cytopenias.
AB - There are various immune cytopenias associated with systemic lupus erythematosus (SLE). The most common one is anemia; however, there are different etiologies for the anemia caused by SLE. Anemia could be due to chronic disease, secondary to renal insufficiency, blood loss, drug induced or autoimmune hemolysis. There are other very rare causes of anemia secondary to SLE which include red cell aplasia, aplastic anemia, and microangiopathic hemolytic anemia. Treatment of the anemia would be according to the cause. Leukopenia, neutropenia, and lymphopenia are hematologic complications associated with SLE, and in majority of cases no treatment is required. Thrombocytopenia is one of the complications of SLE and is usually treated by steroids. However, there are significant numbers of patients which will either not respond to or relapse after treatment. This article summarizes immune cytopenias seen in patients with SLE, and it also discusses management of these cytopenias.
KW - Cytopenia
KW - G-CSF
KW - Growth factors
KW - Hematologic manifestation
KW - SLE
KW - Systemic lupus erythematosus
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U2 - 10.1016/j.autrev.2013.02.001
DO - 10.1016/j.autrev.2013.02.001
M3 - Review article
C2 - 23462431
AN - SCOPUS:84877838218
SN - 1568-9972
VL - 12
SP - 784
EP - 791
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
IS - 7
ER -