Management of intracranial metastatic disease with laser interstitial thermal therapy

Afshin Salehi, Ashwin A. Kamath, Eric C. Leuthardt, Albert H. Kim

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Treatment approaches for metastatic brain tumors continue to evolve, with increasing recent emphasis on focal therapies whenever possible. MRI-guided Laser Interstitial Thermal Therapy (LITT) is a minimally invasive surgical option that has broadened the capability of the neurosurgeon in treating difficult-to-treat intracranial lesions. This technology uses image-guided delivery of laser to the target lesion to generate heat and thereby ablate pathological tissue and has expanded the neurosurgical armamentarium for surgical treatment of brain metastases. In this study, we describe the indications for LITT in the management of intracranial metastatic disease and report our institutional experience with LITT.

Original languageEnglish (US)
Article number499
JournalFrontiers in Oncology
Issue numberOCT
StatePublished - 2018
Externally publishedYes


  • Brain metastases
  • Intracranial metastatic disease
  • Laser interstitial thermal therapy (LITT)
  • Overall survival (OS)
  • Thermal-damage-threshold (TDT)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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