Management of locally advanced rectal cancer

Aaron R. Sasson, Elin R. Sigurdson

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The treatment of rectal cancer typically involves a multidisciplinary approach. A minority of patients will have tumors that are full thickness, involve adjacent structures, or have metastatic disease to regional lymph nodes. The combination of adjuvant therapy and surgical resection is the mainstay of treatment for locally advanced carcinoma of the rectum. This article will review the role of adjuvant chemotherapy and radiotherapy in patients with high risk tumors. The operative considerations in advanced rectal cancers will be reviewed. In particular, the role of mesorectal excision and exenterative surgery will be discussed.

Original languageEnglish (US)
Pages (from-to)193-204
Number of pages12
JournalSurgical Oncology
Issue number4
StatePublished - 2000


  • Adjuvant therapy
  • Advanced rectal cancer
  • Mesorectal excision
  • Pelvic exenteration

ASJC Scopus subject areas

  • Surgery
  • Oncology


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