Management of mucin-producing cystic neoplasms of the pancreas

Stefan Fritz, Andrew L. Warshaw, Sarah P. Thayer

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

During the last decade small lesions of the pancreas have been increasingly recognized in clinical practice. Among these lesions, mucin-producing cystic neoplasms represent a recently described and unique entity among pancreatic tumors. In 1996, the World Health Organization distinguished two different types of muci-nous cystic tumors: intraductal papillary mucinous neoplasms(IPMNs) of the pancreas, which are characterized by mucin production, cystic dilation of the pancreatic ducts, and intrapapillary growth, and muci-nous cystic neoplasms(MCNs), which are defined by ovarian-like stroma and in most cases do not communicate with pancreatic ducts. Further, IPMNs can be subdivided into main-duct type, mixed-type, and branch-duct type tumors. Older data did not distinguish among different subsets of cystic neoplasms of the pancreas, and consequently many databases were inconsistent. Histopathologically, both IPMNs and MCNs demonstrate a wide spectrum of cellular atypia ranging from mild mucinous hyperplasia to invasive adenocarci-noma. Because mucinous cystic neoplasms of the pancreas show significant differences in clinical behavior from patient to patient, knowledge of the clinicopatho-logic characteristics and natural history of specific subtypes of IPMNs and MCNs has become crucial for physicians working in the field of gastroenterology. The present work offers an overview of current and generally accepted clinical guidelines for the diagnosis and treatment of IPMNs and MCNs.

Original languageEnglish (US)
Pages (from-to)125-136
Number of pages12
JournalOncologist
Volume14
Issue number2
DOIs
StatePublished - Feb 2009

Keywords

  • IPMN
  • Intraductal papillary mucinous neoplasm
  • MCN
  • Mucinous cystic neoplasm
  • Pancreas
  • Pancreatectomy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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