Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome with Nephron-sparing Surgery in a Patient with von Hippel-Lindau

John M. DiBianco; Julie Y. An; Sally Tanakchi; Zachary Stanik; Aidan McGowan; Mahir Maruf; Abhinav Sidana; Amit Lodha Jain; Akhil Muthigi; Arvin K. George; Christopher Bayne; W. Marston Linehan; Shawna L. Boyle; Adam R. Metwalli

doi:10.1016/j.eucr.2017.02.015

Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome with Nephron-sparing Surgery in a Patient with von Hippel-Lindau

John M. DiBianco, Julie Y. An, Sally Tanakchi, Zachary Stanik, Aidan McGowan, Mahir Maruf, Abhinav Sidana, Amit Lodha Jain, Akhil Muthigi, Arvin K. George, Christopher Bayne, W. Marston Linehan, Shawna L. Boyle, Adam R. Metwalli

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Abstract

A patient with germline von Hippel-Lindau (VHL) gene alteration and history of multiple tumors present with classical paraneoplastic syndrome (PNS) associated with renal cell carcinoma (RCC). She underwent open nephron sparing surgery with resolution of symptoms. She remained without recurrence of RCC for the initial 2 years of her follow-up. To the best of our knowledge, this case represents the first in which PNS was specifically resolved using a partial nephrectomy in a patient with VHL. This case report provides initial evidence for the potential role of nephron sparing surgery in the management of paraneoplastic symptoms associated with hereditary RCC.

Original language	English (US)
Pages (from-to)	101-103
Number of pages	3
Journal	Urology Case Reports
Volume	13
DOIs	https://doi.org/10.1016/j.eucr.2017.02.015
State	Published - Jul 1 2017
Externally published	Yes

Keywords

Oncology
Paraneoplastic
Partial nephrectomy
RCC
VHL

ASJC Scopus subject areas

Urology

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10.1016/j.eucr.2017.02.015

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DiBianco, J. M., An, J. Y., Tanakchi, S., Stanik, Z., McGowan, A., Maruf, M., Sidana, A., Jain, A. L., Muthigi, A., George, A. K., Bayne, C., Linehan, W. M., Boyle, S. L., & Metwalli, A. R. (2017). Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome with Nephron-sparing Surgery in a Patient with von Hippel-Lindau. Urology Case Reports, 13, 101-103. https://doi.org/10.1016/j.eucr.2017.02.015

DiBianco, JM, An, JY, Tanakchi, S, Stanik, Z, McGowan, A, Maruf, M, Sidana, A, Jain, AL, Muthigi, A, George, AK, Bayne, C, Linehan, WM, Boyle, SL & Metwalli, AR 2017, 'Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome with Nephron-sparing Surgery in a Patient with von Hippel-Lindau', Urology Case Reports, vol. 13, pp. 101-103. https://doi.org/10.1016/j.eucr.2017.02.015

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title = "Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome with Nephron-sparing Surgery in a Patient with von Hippel-Lindau",

abstract = "A patient with germline von Hippel-Lindau (VHL) gene alteration and history of multiple tumors present with classical paraneoplastic syndrome (PNS) associated with renal cell carcinoma (RCC). She underwent open nephron sparing surgery with resolution of symptoms. She remained without recurrence of RCC for the initial 2 years of her follow-up. To the best of our knowledge, this case represents the first in which PNS was specifically resolved using a partial nephrectomy in a patient with VHL. This case report provides initial evidence for the potential role of nephron sparing surgery in the management of paraneoplastic symptoms associated with hereditary RCC.",

keywords = "Oncology, Paraneoplastic, Partial nephrectomy, RCC, VHL",

author = "DiBianco, {John M.} and An, {Julie Y.} and Sally Tanakchi and Zachary Stanik and Aidan McGowan and Mahir Maruf and Abhinav Sidana and Jain, {Amit Lodha} and Akhil Muthigi and George, {Arvin K.} and Christopher Bayne and Linehan, {W. Marston} and Boyle, {Shawna L.} and Metwalli, {Adam R.}",

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doi = "10.1016/j.eucr.2017.02.015",

language = "English (US)",

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AU - DiBianco, John M.

AU - An, Julie Y.

AU - Tanakchi, Sally

AU - Stanik, Zachary

AU - McGowan, Aidan

AU - Maruf, Mahir

AU - Sidana, Abhinav

AU - Jain, Amit Lodha

AU - Muthigi, Akhil

AU - George, Arvin K.

AU - Bayne, Christopher

AU - Linehan, W. Marston

AU - Boyle, Shawna L.

AU - Metwalli, Adam R.

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AB - A patient with germline von Hippel-Lindau (VHL) gene alteration and history of multiple tumors present with classical paraneoplastic syndrome (PNS) associated with renal cell carcinoma (RCC). She underwent open nephron sparing surgery with resolution of symptoms. She remained without recurrence of RCC for the initial 2 years of her follow-up. To the best of our knowledge, this case represents the first in which PNS was specifically resolved using a partial nephrectomy in a patient with VHL. This case report provides initial evidence for the potential role of nephron sparing surgery in the management of paraneoplastic symptoms associated with hereditary RCC.

KW - Oncology

KW - Paraneoplastic

KW - Partial nephrectomy

KW - RCC

KW - VHL

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Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome with Nephron-sparing Surgery in a Patient with von Hippel-Lindau

Abstract

Keywords

ASJC Scopus subject areas

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