TY - JOUR
T1 - Manifestations of Epstein‐Barr virus‐associated disorders in liver
AU - Markin, Rodney S.
PY - 1994/2
Y1 - 1994/2
N2 - Abstract: Epstein‐Barr virus is a ubiquitous virus associated with a variety of different diseases and disorders. The manifestations of Epstein‐Barr virus‐associated diseases or disorders within the liver, which involve a broad spectrum of histologic and clinical features, ranging from hepatitis through lymphoproliferative disorders to lymphoma, are presented. An important aspect of Epstein‐Barr virus expression and infection is the biology of the Epstein‐Barr virus. Documentation of infection can be performed using serology to detect the interaction of Epstein‐Barr virus with the immune system, and the detection of EBV proteins and use of molecular biologic techniques to identify the presence of EBV RNA, and DNA sequences. Of particular utility are in situ hybridization, Southern blot analysis, and polymerase chain reaction as diagnostic methods to identify specific RNA or DNA sequences. Epstein‐Barr virus‐associated diseases and disorders including infectious mononucleosis, sporadic fatal infectious mononucleosis, X‐linked proliferative disorder (Duncan's disease), post‐transplant lymphoproliferative disorders, lymphoma, and AIDS are discussed. The histopathologic findings present in liver associated with each disease are presented with illustrative examples. Handling the tissue and interaction with clinical services are also discussed as a method for appropriate diagnosis of Epstein‐Barr virus‐driven processes affecting the liver.
AB - Abstract: Epstein‐Barr virus is a ubiquitous virus associated with a variety of different diseases and disorders. The manifestations of Epstein‐Barr virus‐associated diseases or disorders within the liver, which involve a broad spectrum of histologic and clinical features, ranging from hepatitis through lymphoproliferative disorders to lymphoma, are presented. An important aspect of Epstein‐Barr virus expression and infection is the biology of the Epstein‐Barr virus. Documentation of infection can be performed using serology to detect the interaction of Epstein‐Barr virus with the immune system, and the detection of EBV proteins and use of molecular biologic techniques to identify the presence of EBV RNA, and DNA sequences. Of particular utility are in situ hybridization, Southern blot analysis, and polymerase chain reaction as diagnostic methods to identify specific RNA or DNA sequences. Epstein‐Barr virus‐associated diseases and disorders including infectious mononucleosis, sporadic fatal infectious mononucleosis, X‐linked proliferative disorder (Duncan's disease), post‐transplant lymphoproliferative disorders, lymphoma, and AIDS are discussed. The histopathologic findings present in liver associated with each disease are presented with illustrative examples. Handling the tissue and interaction with clinical services are also discussed as a method for appropriate diagnosis of Epstein‐Barr virus‐driven processes affecting the liver.
KW - Burkitt's lymphoma
KW - Epstein Barr virus
KW - infectious mononucleosis
KW - liver
KW - lymphoproliferative diseases
UR - http://www.scopus.com/inward/record.url?scp=0028327807&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028327807&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0676.1994.tb00001.x
DO - 10.1111/j.1600-0676.1994.tb00001.x
M3 - Article
C2 - 8177024
AN - SCOPUS:0028327807
VL - 14
SP - 1
EP - 13
JO - Liver International
JF - Liver International
SN - 1478-3223
IS - 1
ER -