Manifestations of Epstein‐Barr virus‐associated disorders in liver

Abstract: Epstein‐Barr virus is a ubiquitous virus associated with a variety of different diseases and disorders. The manifestations of Epstein‐Barr virus‐associated diseases or disorders within the liver, which involve a broad spectrum of histologic and clinical features, ranging from hepatitis through lymphoproliferative disorders to lymphoma, are presented. An important aspect of Epstein‐Barr virus expression and infection is the biology of the Epstein‐Barr virus. Documentation of infection can be performed using serology to detect the interaction of Epstein‐Barr virus with the immune system, and the detection of EBV proteins and use of molecular biologic techniques to identify the presence of EBV RNA, and DNA sequences. Of particular utility are in situ hybridization, Southern blot analysis, and polymerase chain reaction as diagnostic methods to identify specific RNA or DNA sequences. Epstein‐Barr virus‐associated diseases and disorders including infectious mononucleosis, sporadic fatal infectious mononucleosis, X‐linked proliferative disorder (Duncan's disease), post‐transplant lymphoproliferative disorders, lymphoma, and AIDS are discussed. The histopathologic findings present in liver associated with each disease are presented with illustrative examples. Handling the tissue and interaction with clinical services are also discussed as a method for appropriate diagnosis of Epstein‐Barr virus‐driven processes affecting the liver.