Manipulation of cellular processing bodies and their constituents by viruses

Asit K. Pattnaik, Phat X. Dinh

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The processing bodies (PBs) are a form of cytoplasmic aggregates that house the cellular RNA decay machinery as well as many RNA-binding proteins and mRNAs. The PBs are constitutively present in eukaryotic cells and are involved in maintaining cellular homeostasis by regulating RNA metabolism, cell signaling, and survival. Virus infections result in modification of the PBs and their constituents. Many viruses induce compositionally altered PBs, while many others use specific components of the PBs for their replication. PB constituents are also known to restrict virus replication by a variety of mechanisms. Further, continuing studies in this rapidly emerging field of PB-virus interactions will undoubtedly provide important clues to the understanding of the role of PBs in cellular homeostasis as well as their role in virus infections and innate immune signaling.

Original languageEnglish (US)
Pages (from-to)286-291
Number of pages6
JournalDNA and Cell Biology
Volume32
Issue number6
DOIs
StatePublished - Jun 1 2013

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

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