MANTA Versus Suture-based Closure Devices Following Transcatheter Aortic Valve Replacement: An Updated Meta-analysis

Ahmad Al-Abdouh, Waiel Abusnina, Mohammed Mhanna, Mahmoud Barbarawi, Ahmad Jabri, Anas Bizanti, Ahmed Abdel-Latif, Andrew M. Goldsweig, Mohamad Alkhouli, Hady Lichaa, Jimmy Kerrigan, Timir K. Paul

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Background: Vascular access closure is essential in large-bore arteriotomy procedures, such as transcatheter aortic valve replacement. ​Suture-based devices are frequently used for vascular access closure. MANTA (Teleflex) is a collagen plug–based device used to achieve hemostasis with evolving efficacy and safety data. This study aimed to evaluate plug-based versus suture-based closure devices following large-bore arteriotomy procedures. Methods: We conducted a systematic review searching PubMed, Cochrane Library, and ClinicalTrials.gov (inception through November 2021) for studies evaluating plug-based versus suture-based closure devices following large-bore arteriotomy procedures. We performed a meta-analysis comparing the length of stay, device failure, mortality, bleeding, and vascular complications between these 2 types of devices. Results: Eleven studies (2 randomized controlled trials and 9 observational studies) with a total of 3123 patients were included in this analysis. Compared with suture-based devices, plug-based devices were associated with a significant decrease in the length of stay (standardized mean difference: −0.14; 95% CI, −0.25 to −0.03) and vascular closure device failure (odds ratio, 0.63; 95% CI, 0.44-0.91) following the procedure. There were no significant differences in all-cause mortality, major or minor bleeding, and major or minor vascular complications between plug-based and suture-based closure devices. Conclusions: Plug-based vascular closure devices were associated with a shorter length of stay and lower risk of device failure following large-bore arteriotomy procedures without differences in mortality, bleeding, or vascular complications than suture-based closure devices.

Original languageEnglish (US)
Article number100397
JournalJournal of the Society for Cardiovascular Angiography and Interventions
Volume1
Issue number5
DOIs
StatePublished - Sep 1 2022

Keywords

  • MANTA
  • arteriotomy
  • plug-based
  • suture-based
  • vascular closure device

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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