TY - JOUR
T1 - Mantle-Cell Lymphoma
AU - Armitage, James O.
AU - Longo, Dan L.
N1 - Publisher Copyright:
© 2022 Massachusetts Medical Society.
PY - 2022/6/30
Y1 - 2022/6/30
N2 - For many years, pathologists were aware of a lymphoma of small lymphocytes that did not fit into existing classifications. Early names proposed for this lymphoma with a diffuse growth pattern were intermediate lymphocytic lymphoma and centrocytic lymphoma.1,2 Mantle-zone lymphoma was the name for the same lymphoma in expanded mantle zones3; in addition to a typical morphologic appearance, this lymphoma had a characteristic immunophenotype (i.e., CD5+, CD10−, Bcl-2+, Bcl-6−, CD20+), with the t(11;14)(q13;q32) chromosomal translocation, and expression of cyclin D1. In 1990, t(11;14) was shown to be associated with intermediate lymphocytic lymphoma and centrocytic lymphoma.4,5 In 1991, Raffeld and Jaffe first proposed the term mantle-cell lymphoma.6 Previously, mantle-cell lymphomas were given a variety of names based on the then-extant criteria for histologic classification; often they were confused with small lymphocytic lymphoma or were named diffuse small-cleaved-cell lymphoma. Other names they were given include lymphoblastic lymphoma, diffuse large-B-cell lymphoma, or follicular lymphoma. Initial studies of survival among patients treated for mantle-cell lymphoma showed a poor outcome after standard chemotherapy with cyclophosphamide, vincristine, and prednisone (CVP) and cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), with a median survival of approximately 3 years, and long-term disease-free survival was rare.7,8 However, with the development of rituximab and regimens specific for this disorder, survival has improved.
AB - For many years, pathologists were aware of a lymphoma of small lymphocytes that did not fit into existing classifications. Early names proposed for this lymphoma with a diffuse growth pattern were intermediate lymphocytic lymphoma and centrocytic lymphoma.1,2 Mantle-zone lymphoma was the name for the same lymphoma in expanded mantle zones3; in addition to a typical morphologic appearance, this lymphoma had a characteristic immunophenotype (i.e., CD5+, CD10−, Bcl-2+, Bcl-6−, CD20+), with the t(11;14)(q13;q32) chromosomal translocation, and expression of cyclin D1. In 1990, t(11;14) was shown to be associated with intermediate lymphocytic lymphoma and centrocytic lymphoma.4,5 In 1991, Raffeld and Jaffe first proposed the term mantle-cell lymphoma.6 Previously, mantle-cell lymphomas were given a variety of names based on the then-extant criteria for histologic classification; often they were confused with small lymphocytic lymphoma or were named diffuse small-cleaved-cell lymphoma. Other names they were given include lymphoblastic lymphoma, diffuse large-B-cell lymphoma, or follicular lymphoma. Initial studies of survival among patients treated for mantle-cell lymphoma showed a poor outcome after standard chemotherapy with cyclophosphamide, vincristine, and prednisone (CVP) and cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), with a median survival of approximately 3 years, and long-term disease-free survival was rare.7,8 However, with the development of rituximab and regimens specific for this disorder, survival has improved.
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U2 - 10.1056/NEJMra2202672
DO - 10.1056/NEJMra2202672
M3 - Review article
C2 - 35767440
AN - SCOPUS:85133214711
SN - 0028-4793
VL - 386
SP - 2495
EP - 2506
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 26
ER -