Mantle cell lymphoma with plasma cell differentiation

Ken H. Young, Wing C. Chan, Kai Fu, Javeed Iqbal, Warren G. Sanger, Anne Ratashak, Timothy C. Greiner, Dennis D. Weisenburger

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

The differentiation of B lymphocytes into plasma cells (PCs) is an antigen-mediated process that largely depends on the interaction between B cells and regulatory factors in their microenvironment. Long-lived PCs are derived from activated B cells in the germinal center (GC), whereas PC differentiation from naive B cells occurs in the extrafollicular areas and the PCs are short-lived. Consequently, lymphomas arising from post-GC B cells often exhibit plasmacytic differentiation, whereas lymphomas arising from naive B cells less commonly show plasmacytic differentiation. Herein, we report 2 cases of mantle cell lymphoma (MCL) with clonal PC differentiation. Both cases presented with the typical cytologic features of MCL and were characterized by a nodular and mantle-zone growth pattern. Clusters of clonal PCs with monotypic κ light chain expression were identified in the centers of the tumor nodules and within reactive GCs. FICTION (Fluorescence immunophenotyping and Interphase Cytogenetics as a Tool for the Investigation Of Neoplasms) analysis demonstrated the characteristic t(11;14)(q13;q32) in both the MCL cells and clonal PCs, indicating that both cell types were derived from the same B-cell clone. These findings indicate that the clonal PC differentiation may occur within GCs in some cases of MCL.

Original languageEnglish (US)
Pages (from-to)954-961
Number of pages8
JournalAmerican Journal of Surgical Pathology
Volume30
Issue number8
DOIs
StatePublished - Aug 1 2006

Keywords

  • FICTION
  • Germinal center
  • Mantle cell lymphoma
  • Plasma cell differentiation

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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