Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse

Cindy Luongo, Karen A. Gould, Li Kuo Su, Kenneth W. Kinzler, Bert Vogelstein, William Dietrich, Eric S. Lander, Amy Rapaich Moser

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45 Scopus citations

Abstract

The Min (multiple intestinal neoplasia) mutation of the mouse has been mapped by analyzing the inheritance of restriction fragment length polymorphisms and simple sequence length polymorphisms in progeny from two intraspecific crosses segregating for the Min mutation. Min, a mutant allele of Apc, the mouse homolog of the human APC (adenomatous polyposis coli) gene, maps to proximal chromosome 18. The synteny between Apc and Mcc, the mouse homolog of the human MCC (mutated in colorectal cancer) gene, is conserved between mouse and human, although the gene order in the Apc to Mcc interval is different from that in the APC to MCC interval.

Original languageEnglish (US)
Pages (from-to)3-8
Number of pages6
JournalGenomics
Volume15
Issue number1
DOIs
StatePublished - Jan 1993

ASJC Scopus subject areas

  • Genetics

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    Luongo, C., Gould, K. A., Su, L. K., Kinzler, K. W., Vogelstein, B., Dietrich, W., Lander, E. S., & Moser, A. R. (1993). Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse. Genomics, 15(1), 3-8. https://doi.org/10.1006/geno.1993.1002