Mapping of the human complement factor I gene to 4q25

Rita Shiang; Jeffrey C. Murray; Cynthia C. Morton; Kenneth H. Buetow; John J. Wasmuth; Ann Haskins Olney; Warren G. Sanger; Gabriel Goldberger

doi:10.1016/0888-7543(89)90318-2

Mapping of the human complement factor I gene to 4q25

Rita Shiang, Jeffrey C. Murray, Cynthia C. Morton, Kenneth H. Buetow, John J. Wasmuth, Ann Haskins Olney, Warren G. Sanger, Gabriel Goldberger

Cytogenetics

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

A detailed genetic and physical map of human complement factor I (IF) using somatic cell hybrids, in situ hybridization, and genetic linkage is reported. The gene has been localized to band 4q25. The order GC-INP10-ADH3-EGF-IF-IL2-MNS is proposed for genes on 4q on the basis of genetic and physical mapping techniques. A BclI polymorphism found with the IF probe demonstrated a maternal origin for a de novo deletion of chromosome 4 that was used in physically mapping the gene. The genetic and physical distances around band 4q24 suggest that 1 cM is approximately 1.2 million bp of DNA. This work provides a useful addition to the map of 4q.

Original language	English (US)
Pages (from-to)	82-86
Number of pages	5
Journal	Genomics
Volume	4
Issue number	1
DOIs	https://doi.org/10.1016/0888-7543(89)90318-2
State	Published - Jan 1989

ASJC Scopus subject areas

Genetics

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title = "Mapping of the human complement factor I gene to 4q25",

abstract = "A detailed genetic and physical map of human complement factor I (IF) using somatic cell hybrids, in situ hybridization, and genetic linkage is reported. The gene has been localized to band 4q25. The order GC-INP10-ADH3-EGF-IF-IL2-MNS is proposed for genes on 4q on the basis of genetic and physical mapping techniques. A BclI polymorphism found with the IF probe demonstrated a maternal origin for a de novo deletion of chromosome 4 that was used in physically mapping the gene. The genetic and physical distances around band 4q24 suggest that 1 cM is approximately 1.2 million bp of DNA. This work provides a useful addition to the map of 4q.",

author = "Rita Shiang and Murray, {Jeffrey C.} and Morton, {Cynthia C.} and Buetow, {Kenneth H.} and Wasmuth, {John J.} and Olney, {Ann Haskins} and Sanger, {Warren G.} and Gabriel Goldberger",

year = "1989",

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doi = "10.1016/0888-7543(89)90318-2",

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T1 - Mapping of the human complement factor I gene to 4q25

AU - Shiang, Rita

AU - Murray, Jeffrey C.

AU - Morton, Cynthia C.

AU - Buetow, Kenneth H.

AU - Wasmuth, John J.

AU - Olney, Ann Haskins

AU - Sanger, Warren G.

AU - Goldberger, Gabriel

PY - 1989/1

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AB - A detailed genetic and physical map of human complement factor I (IF) using somatic cell hybrids, in situ hybridization, and genetic linkage is reported. The gene has been localized to band 4q25. The order GC-INP10-ADH3-EGF-IF-IL2-MNS is proposed for genes on 4q on the basis of genetic and physical mapping techniques. A BclI polymorphism found with the IF probe demonstrated a maternal origin for a de novo deletion of chromosome 4 that was used in physically mapping the gene. The genetic and physical distances around band 4q24 suggest that 1 cM is approximately 1.2 million bp of DNA. This work provides a useful addition to the map of 4q.

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