@article{10e2bfb264e244b6ba21f8349299985e,
title = "Mapping of the human complement factor I gene to 4q25",
abstract = "A detailed genetic and physical map of human complement factor I (IF) using somatic cell hybrids, in situ hybridization, and genetic linkage is reported. The gene has been localized to band 4q25. The order GC-INP10-ADH3-EGF-IF-IL2-MNS is proposed for genes on 4q on the basis of genetic and physical mapping techniques. A BclI polymorphism found with the IF probe demonstrated a maternal origin for a de novo deletion of chromosome 4 that was used in physically mapping the gene. The genetic and physical distances around band 4q24 suggest that 1 cM is approximately 1.2 million bp of DNA. This work provides a useful addition to the map of 4q.",
author = "Rita Shiang and Murray, {Jeffrey C.} and Morton, {Cynthia C.} and Buetow, {Kenneth H.} and Wasmuth, {John J.} and Olney, {Ann Haskins} and Sanger, {Warren G.} and Gabriel Goldberger",
note = "Funding Information: This work was supported by NIH Grants ROl-HD20998 (J.C.M.) and GM 33293 (G.G.). R.S. was supported by NIH Predoctoral Training Grant T32-GM07091. C.C.M. was supported by NIH Postdoctoral Fellowship CA-07511. Excellent administrative assistance was supplied by LaRas Rudin and Nancy Newkirk. CEPH generously supplied DNA and analysis software. Graeme Bell donated the EGF probe, Moyra Smith the ADH3 probe, and Vern Paetkau the IL2 probe. We especially thank the families and individuals whose donated material allowed establishment of the cell lines.",
year = "1989",
month = jan,
doi = "10.1016/0888-7543(89)90318-2",
language = "English (US)",
volume = "4",
pages = "82--86",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "1",
}