Mash-1 is expressed during ROD photoreceptor differentiation and binds an E-box, Eopsin-1 in the rat opsin gene

Iqbal Ahmad

doi:10.1016/0165-3806(96)83500-0

Mash-1 is expressed during ROD photoreceptor differentiation and binds an E-box, E_opsin-1 in the rat opsin gene

Iqbal Ahmad

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

It has been shown previously that the transcription factor Mash-1 plays a significant role in mammalian neurogenesis. In the present study we show that Mash-1 is expressed during rat retinal development and that it interacts specifically with an E-box identified in the promoter of the opsin gene during rod photoreceptor differentiation. We propose that opsin may be one of the downstream neuronal genes regulated by Mash-1 during neurogenesis in the central nervous system.

Original language	English (US)
Pages (from-to)	184-189
Number of pages	6
Journal	Developmental Brain Research
Volume	90
Issue number	1-2
DOIs	https://doi.org/10.1016/0165-3806(96)83500-0
State	Published - Dec 21 1995

Keywords

Mash-1
Neurogenesis
Opsin
Photoreceptor
Retina
bHLH protein

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

Access to Document

10.1016/0165-3806(96)83500-0

Cite this

@article{080c7fb0d4a144bfbad2e8dcf0b635f8,

title = "Mash-1 is expressed during ROD photoreceptor differentiation and binds an E-box, Eopsin-1 in the rat opsin gene",

abstract = "It has been shown previously that the transcription factor Mash-1 plays a significant role in mammalian neurogenesis. In the present study we show that Mash-1 is expressed during rat retinal development and that it interacts specifically with an E-box identified in the promoter of the opsin gene during rod photoreceptor differentiation. We propose that opsin may be one of the downstream neuronal genes regulated by Mash-1 during neurogenesis in the central nervous system.",

keywords = "Mash-1, Neurogenesis, Opsin, Photoreceptor, Retina, bHLH protein",

author = "Iqbal Ahmad",

note = "Funding Information: We would like to thank Xiao-Hong Sun and Robert Benezra for E12 and Id constructs, David Anderson for Mash-1 antibody, David Turner and Preston Gadson for critical comments, Angie Rizzino for helpful suggestions, Dorisa Polk and Connie Dooley for reading the manuscript, Robert Norgren for the use of his microscope, Colin Barnstable in whose lab the initial stage of this work for the NIH First Award was carried out and Huai-Yun Han for technical assistance. This work is supported by NEI R2910313.",

year = "1995",

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doi = "10.1016/0165-3806(96)83500-0",

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T1 - Mash-1 is expressed during ROD photoreceptor differentiation and binds an E-box, Eopsin-1 in the rat opsin gene

AU - Ahmad, Iqbal

N1 - Funding Information: We would like to thank Xiao-Hong Sun and Robert Benezra for E12 and Id constructs, David Anderson for Mash-1 antibody, David Turner and Preston Gadson for critical comments, Angie Rizzino for helpful suggestions, Dorisa Polk and Connie Dooley for reading the manuscript, Robert Norgren for the use of his microscope, Colin Barnstable in whose lab the initial stage of this work for the NIH First Award was carried out and Huai-Yun Han for technical assistance. This work is supported by NEI R2910313.

PY - 1995/12/21

Y1 - 1995/12/21

N2 - It has been shown previously that the transcription factor Mash-1 plays a significant role in mammalian neurogenesis. In the present study we show that Mash-1 is expressed during rat retinal development and that it interacts specifically with an E-box identified in the promoter of the opsin gene during rod photoreceptor differentiation. We propose that opsin may be one of the downstream neuronal genes regulated by Mash-1 during neurogenesis in the central nervous system.

AB - It has been shown previously that the transcription factor Mash-1 plays a significant role in mammalian neurogenesis. In the present study we show that Mash-1 is expressed during rat retinal development and that it interacts specifically with an E-box identified in the promoter of the opsin gene during rod photoreceptor differentiation. We propose that opsin may be one of the downstream neuronal genes regulated by Mash-1 during neurogenesis in the central nervous system.

KW - Mash-1

KW - Neurogenesis

KW - Opsin

KW - Photoreceptor

KW - Retina

KW - bHLH protein

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