Mash-1 is expressed during ROD photoreceptor differentiation and binds an E-box, Eopsin-1 in the rat opsin gene

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Abstract

It has been shown previously that the transcription factor Mash-1 plays a significant role in mammalian neurogenesis. In the present study we show that Mash-1 is expressed during rat retinal development and that it interacts specifically with an E-box identified in the promoter of the opsin gene during rod photoreceptor differentiation. We propose that opsin may be one of the downstream neuronal genes regulated by Mash-1 during neurogenesis in the central nervous system.

Original languageEnglish (US)
Pages (from-to)184-189
Number of pages6
JournalDevelopmental Brain Research
Volume90
Issue number1-2
DOIs
StatePublished - Dec 21 1995

Keywords

  • Mash-1
  • Neurogenesis
  • Opsin
  • Photoreceptor
  • Retina
  • bHLH protein

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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