Massive occlusive thrombosis of the pulmonary artery in pigtailed macaques chronically infected with R5-tropic simian-human immunodeficiency virus

Cynthia L. Courtney, Kelly F. Ethun, Francois Villinger, Ruth M. Ruprecht, Siddappa N. Byrareddy

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background: Pulmonary arterial hypertension (PAH) has been identified as a serious complication of HIV infection. Methods and Results: Here, we report sudden death in two pigtailed macaques (Macaca nemestrina) chronically infected (~1-2 years post-infection) with an R5 SHIV strain. At necropsy, total occlusion of the pulmonary artery by a large fibrin thrombus was present in both animals. Conclusion: This report describes pulmonary vascular lesions similar to PAH in R5 SHIV-infected pigtail macaques.

Original languageEnglish (US)
Pages (from-to)35-39
Number of pages5
JournalJournal of medical primatology
Volume44
Issue number1
DOIs
StatePublished - Feb 1 2015

Keywords

  • Pulmonary arterial hypertension
  • SHIV
  • SIV

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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