Background: Pulmonary arterial hypertension (PAH) has been identified as a serious complication of HIV infection. Methods and Results: Here, we report sudden death in two pigtailed macaques (Macaca nemestrina) chronically infected (~1-2 years post-infection) with an R5 SHIV strain. At necropsy, total occlusion of the pulmonary artery by a large fibrin thrombus was present in both animals. Conclusion: This report describes pulmonary vascular lesions similar to PAH in R5 SHIV-infected pigtail macaques.
- Pulmonary arterial hypertension
ASJC Scopus subject areas
- Animal Science and Zoology