TY - GEN
T1 - Mathematical modeling of macrophage activation in left ventricular remodeling post-myocardial infarction
AU - Wang, Yunji
AU - Jin, Yufang
AU - Ma, Yonggang
AU - Halade, Ganesh V.
AU - Linsey, Merry L.
PY - 2011
Y1 - 2011
N2 - The macrophage plays a key role in regulating the remodeling of the left ventricle (LV) post-myocardial infarction (MI). However, the underlying regulatory mechanisms of macrophage activations were understudied. The goal of this study, therefore, was to establish a framework for macrophage activations and build a mathematical model based on the framework by integrating computational and experimental approaches. Accordingly, we established a framework including myocytes, monocytes, macrophages, and interlukin-1 (IL-1), IL-10, and tumor necrosis-alpha (TNF-α) based on literature, established a set of ordinary differential equations as the mathematical model, and primarily validated the model with experimental results. This study provides a useful tool to further study macrophage activations.
AB - The macrophage plays a key role in regulating the remodeling of the left ventricle (LV) post-myocardial infarction (MI). However, the underlying regulatory mechanisms of macrophage activations were understudied. The goal of this study, therefore, was to establish a framework for macrophage activations and build a mathematical model based on the framework by integrating computational and experimental approaches. Accordingly, we established a framework including myocytes, monocytes, macrophages, and interlukin-1 (IL-1), IL-10, and tumor necrosis-alpha (TNF-α) based on literature, established a set of ordinary differential equations as the mathematical model, and primarily validated the model with experimental results. This study provides a useful tool to further study macrophage activations.
UR - http://www.scopus.com/inward/record.url?scp=84863637709&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863637709&partnerID=8YFLogxK
U2 - 10.1109/gensips.2011.6169480
DO - 10.1109/gensips.2011.6169480
M3 - Conference contribution
AN - SCOPUS:84863637709
SN - 9781467304900
T3 - Proceedings - IEEE International Workshop on Genomic Signal Processing and Statistics
SP - 202
EP - 205
BT - Proceedings 2011 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS'11
PB - IEEE Computer Society
T2 - 2011 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS'11
Y2 - 4 December 2011 through 6 December 2011
ER -