Mathematical modeling of macrophage activation in left ventricular remodeling post-myocardial infarction

Yunji Wang, Yufang Jin, Yonggang Ma, Ganesh V. Halade, Merry L. Linsey

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

The macrophage plays a key role in regulating the remodeling of the left ventricle (LV) post-myocardial infarction (MI). However, the underlying regulatory mechanisms of macrophage activations were understudied. The goal of this study, therefore, was to establish a framework for macrophage activations and build a mathematical model based on the framework by integrating computational and experimental approaches. Accordingly, we established a framework including myocytes, monocytes, macrophages, and interlukin-1 (IL-1), IL-10, and tumor necrosis-alpha (TNF-α) based on literature, established a set of ordinary differential equations as the mathematical model, and primarily validated the model with experimental results. This study provides a useful tool to further study macrophage activations.

Original languageEnglish (US)
Title of host publicationProceedings 2011 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS'11
PublisherIEEE Computer Society
Pages202-205
Number of pages4
ISBN (Print)9781467304900
DOIs
StatePublished - 2011
Externally publishedYes
Event2011 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS'11 - San Antonio, TX, United States
Duration: Dec 4 2011Dec 6 2011

Publication series

NameProceedings - IEEE International Workshop on Genomic Signal Processing and Statistics
ISSN (Print)2150-3001
ISSN (Electronic)2150-301X

Other

Other2011 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS'11
Country/TerritoryUnited States
CitySan Antonio, TX
Period12/4/1112/6/11

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Computational Theory and Mathematics
  • Signal Processing
  • Biomedical Engineering

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