Matrix metalloproteinase-12 as an endogenous resolution promoting factor following myocardial infarction

Alan J. Mouton; Osvaldo J. Rivera Gonzalez; Amanda R. Kaminski; Edwin T. Moore; Merry L. Lindsey

doi:10.1016/j.phrs.2018.10.026

Matrix metalloproteinase-12 as an endogenous resolution promoting factor following myocardial infarction

Alan J. Mouton, Osvaldo J. Rivera Gonzalez, Amanda R. Kaminski, Edwin T. Moore, Merry L. Lindsey

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Following myocardial infarction (MI), timely resolution of inflammation promotes wound healing and scar formation while limiting excessive tissue damage. Resolution promoting factors (RPFs) are agents that blunt leukocyte trafficking and inflammation, promote necrotic and apoptotic cell clearance, and stimulate scar formation. Previously identified RPFs include mediators derived from lipids (resolvins, lipoxins, protectins, and maresins), proteins (glucocorticoids, annexin A1, galectin 1, and melanocortins), or gases (CO, H ₂ S, and NO). Matrix metalloproteinase-12 (MMP-12; macrophage elastase) has shown promising RPF qualities in a variety of disease states. We review here the evidence that MMP-12 may serve as a novel RPF with potential therapeutic efficacy in the setting of MI.

Original language	English (US)
Pages (from-to)	252-258
Number of pages	7
Journal	Pharmacological Research
Volume	137
DOIs	https://doi.org/10.1016/j.phrs.2018.10.026
State	Published - Nov 2018

Keywords

Extracellular matrix
Fibroblast
Inflammation
Inflammation resolution
Macrophage
Neutrophil

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/j.phrs.2018.10.026

Fingerprint Dive into the research topics of 'Matrix metalloproteinase-12 as an endogenous resolution promoting factor following myocardial infarction'. Together they form a unique fingerprint.

Cite this

@article{94ec3c317ecf4b3cac07513df7bb84eb,

title = "Matrix metalloproteinase-12 as an endogenous resolution promoting factor following myocardial infarction",

abstract = " Following myocardial infarction (MI), timely resolution of inflammation promotes wound healing and scar formation while limiting excessive tissue damage. Resolution promoting factors (RPFs) are agents that blunt leukocyte trafficking and inflammation, promote necrotic and apoptotic cell clearance, and stimulate scar formation. Previously identified RPFs include mediators derived from lipids (resolvins, lipoxins, protectins, and maresins), proteins (glucocorticoids, annexin A1, galectin 1, and melanocortins), or gases (CO, H 2 S, and NO). Matrix metalloproteinase-12 (MMP-12; macrophage elastase) has shown promising RPF qualities in a variety of disease states. We review here the evidence that MMP-12 may serve as a novel RPF with potential therapeutic efficacy in the setting of MI. ",

keywords = "Extracellular matrix, Fibroblast, Inflammation, Inflammation resolution, Macrophage, Neutrophil",

author = "Mouton, {Alan J.} and {Rivera Gonzalez}, {Osvaldo J.} and Kaminski, {Amanda R.} and Moore, {Edwin T.} and Lindsey, {Merry L.}",

year = "2018",

month = nov,

doi = "10.1016/j.phrs.2018.10.026",

language = "English (US)",

volume = "137",

pages = "252--258",

journal = "Pharmacological Research",

issn = "1043-6618",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Matrix metalloproteinase-12 as an endogenous resolution promoting factor following myocardial infarction

AU - Mouton, Alan J.

AU - Rivera Gonzalez, Osvaldo J.

AU - Kaminski, Amanda R.

AU - Moore, Edwin T.

AU - Lindsey, Merry L.

PY - 2018/11

Y1 - 2018/11

N2 - Following myocardial infarction (MI), timely resolution of inflammation promotes wound healing and scar formation while limiting excessive tissue damage. Resolution promoting factors (RPFs) are agents that blunt leukocyte trafficking and inflammation, promote necrotic and apoptotic cell clearance, and stimulate scar formation. Previously identified RPFs include mediators derived from lipids (resolvins, lipoxins, protectins, and maresins), proteins (glucocorticoids, annexin A1, galectin 1, and melanocortins), or gases (CO, H 2 S, and NO). Matrix metalloproteinase-12 (MMP-12; macrophage elastase) has shown promising RPF qualities in a variety of disease states. We review here the evidence that MMP-12 may serve as a novel RPF with potential therapeutic efficacy in the setting of MI.

AB - Following myocardial infarction (MI), timely resolution of inflammation promotes wound healing and scar formation while limiting excessive tissue damage. Resolution promoting factors (RPFs) are agents that blunt leukocyte trafficking and inflammation, promote necrotic and apoptotic cell clearance, and stimulate scar formation. Previously identified RPFs include mediators derived from lipids (resolvins, lipoxins, protectins, and maresins), proteins (glucocorticoids, annexin A1, galectin 1, and melanocortins), or gases (CO, H 2 S, and NO). Matrix metalloproteinase-12 (MMP-12; macrophage elastase) has shown promising RPF qualities in a variety of disease states. We review here the evidence that MMP-12 may serve as a novel RPF with potential therapeutic efficacy in the setting of MI.

KW - Extracellular matrix

KW - Fibroblast

KW - Inflammation

KW - Inflammation resolution

KW - Macrophage

KW - Neutrophil

UR - http://www.scopus.com/inward/record.url?scp=85055735258&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055735258&partnerID=8YFLogxK

U2 - 10.1016/j.phrs.2018.10.026

DO - 10.1016/j.phrs.2018.10.026

M3 - Review article

C2 - 30394317

AN - SCOPUS:85055735258

VL - 137

SP - 252

EP - 258

JO - Pharmacological Research

JF - Pharmacological Research

SN - 1043-6618

ER -