Matrix metalloproteinase-12 as an endogenous resolution promoting factor following myocardial infarction

Alan J. Mouton, Osvaldo J. Rivera Gonzalez, Amanda R. Kaminski, Edwin T. Moore, Merry L. Lindsey

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Following myocardial infarction (MI), timely resolution of inflammation promotes wound healing and scar formation while limiting excessive tissue damage. Resolution promoting factors (RPFs) are agents that blunt leukocyte trafficking and inflammation, promote necrotic and apoptotic cell clearance, and stimulate scar formation. Previously identified RPFs include mediators derived from lipids (resolvins, lipoxins, protectins, and maresins), proteins (glucocorticoids, annexin A1, galectin 1, and melanocortins), or gases (CO, H 2 S, and NO). Matrix metalloproteinase-12 (MMP-12; macrophage elastase) has shown promising RPF qualities in a variety of disease states. We review here the evidence that MMP-12 may serve as a novel RPF with potential therapeutic efficacy in the setting of MI.

Original languageEnglish (US)
Pages (from-to)252-258
Number of pages7
JournalPharmacological Research
Volume137
DOIs
StatePublished - Nov 2018

Keywords

  • Extracellular matrix
  • Fibroblast
  • Inflammation
  • Inflammation resolution
  • Macrophage
  • Neutrophil

ASJC Scopus subject areas

  • Pharmacology

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