Matrix metalloproteinase-9: Many shades of function in cardiovascular disease

Andriy Yabluchanskiy, Yonggang Ma, Rugmani Padmanabhan Iyer, Michael E. Hall, Merry L. Lindsey

Research output: Contribution to journalReview article

188 Scopus citations

Abstract

Matrix metalloproteinase (MMP)-9, one of the most widely investigated MMPs, regulates pathological remodeling processes that involve inflammation and fibrosis in cardiovascular disease. MMP-9 directly degrades extracellular matrix (ECM) proteins and activates cytokines and chemokines to regulate tissue remodeling. MMP-9 deletion or inhibition has proven overall beneficial in multiple animal models of cardiovascular disease. As such, MMP-9 expression and activity is a common end point measured. MMP-9 cell-specific overexpression, however, has also proven beneficial and highlights the fact that little information is available on the underlying mechanisms of MMP-9 function. In this review, we summarize our current understanding of MMP-9 physiology, including structure, regulation, activation, and downstream effects of increased MMP-9. We discuss MMP-9 roles during inflammation and fibrosis in cardiovascular disease. By concentrating on the substrates of MMP-9 and their roles in cardiovascular disease, we explore the overall function and discuss future directions on the translational potential of MMP-9 based therapies.

Original languageEnglish (US)
Pages (from-to)391-403
Number of pages13
JournalPhysiology
Volume28
Issue number6
DOIs
StatePublished - Nov 1 2013

ASJC Scopus subject areas

  • Physiology

Fingerprint Dive into the research topics of 'Matrix metalloproteinase-9: Many shades of function in cardiovascular disease'. Together they form a unique fingerprint.

  • Cite this