Matrix Metalloproteinases in Myocardial Infarction and Heart Failure

Kristine Y. DeLeon-Pennell, Cesar A. Meschiari, Mira Jung, Merry L. Lindsey

Research output: Chapter in Book/Report/Conference proceedingChapter

51 Scopus citations

Abstract

Cardiovascular disease is the leading cause of death, accounting for 600,000 deaths each year in the United States. In addition, heart failure accounts for 37% of health care spending. Matrix metalloproteinases (MMPs) increase after myocardial infarction (MI) and correlate with left ventricular dysfunction in heart failure patients. MMPs regulate the remodeling process by facilitating extracellular matrix turnover and inflammatory signaling. Due to the critical role MMPs play during cardiac remodeling, there is a need to better understand the pathophysiological mechanism of MMPs, including the biological function of the downstream products of MMP proteolysis. Future studies developing new therapeutic targets that inhibit specific MMP actions to limit the development of heart failure post-MI are warranted. This chapter focuses on the role of MMPs post-MI, the efficiency of MMPs as biomarkers for MI or heart failure, and the future of MMPs and their cleavage products as targets for prevention of post-MI heart failure.

Original languageEnglish (US)
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier B.V.
Pages75-100
Number of pages26
DOIs
StatePublished - 2017

Publication series

NameProgress in Molecular Biology and Translational Science
Volume147
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814

Keywords

  • Fibrosis
  • Heart failure
  • Inflammation
  • Matrix metalloproteinases
  • Myocardial infarction
  • Omics

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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  • Cite this

    DeLeon-Pennell, K. Y., Meschiari, C. A., Jung, M., & Lindsey, M. L. (2017). Matrix Metalloproteinases in Myocardial Infarction and Heart Failure. In Progress in Molecular Biology and Translational Science (pp. 75-100). (Progress in Molecular Biology and Translational Science; Vol. 147). Elsevier B.V.. https://doi.org/10.1016/bs.pmbts.2017.02.001